This grant aims to significantly advance Type 1 Diabetes (T1D) understanding and management through research on extracellular vesicles (EVs) from human pancreatic islets. Its primary purpose is to develop tools and platforms for precise EV purification and characterization from healthy, T1D, and at-risk individuals. The initiative will explore how pancreatic EV biology contributes to islet function, dysfunction, and T1D initiation. A crucial component involves developing innovative EV-based diagnostic tools for improved disease monitoring and classification. Ultimately, this research seeks to leverage pancreatic EV insights to identify novel therapeutic targets, offering new avenues for T1D treatment and prevention.
Opportunity ID: 333977
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DK-21-016 |
| Funding Opportunity Title: | Characterization of Islet-derived Extracellular Vesicles for Improved Detection, Monitoring, Classification, and Treatment of Type 1 Diabetes (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Food and Nutrition Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jun 03, 2021 |
| Last Updated Date: | Jun 03, 2021 |
| Original Closing Date for Applications: | Nov 03, 2021 |
| Current Closing Date for Applications: | Nov 03, 2021 |
| Archive Date: | Dec 09, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Public and State controlled institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts County governments Native American tribal governments (Federally recognized) For profit organizations other than small businesses Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities City or township governments Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This initiative will support the development of tools and experimental platforms for the purification and characterization of Extracellular Vesicles (EV) originating from the human pancreatic islet and its broader tissue environment in healthy individuals, and individuals with T1D or at-risk of developing the disease. It will also support the exploration of the contribution of pancreatic EV biology to islet function, dysfunction and T1D disease initiation; the development of EV-based diagnostic tools for disease monitoring and classification; and the use of pancreatic EV biology to identify novel therapeutic targets. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-21-016.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00269866 | Oct 28, 2021 | Nov 03, 2021 | View | |
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00267528 | Oct 03, 2021 | Jan 24, 2022 | View |
Package 1
Mandatory forms
333977 RR_SF424_5_0-5.0.pdf
333977 PHS398_CoverPageSupplement_5_0-5.0.pdf
333977 RR_OtherProjectInfo_1_4-1.4.pdf
333977 PerformanceSite_4_0-4.0.pdf
333977 RR_KeyPersonExpanded_4_0-4.0.pdf
333977 PHS398_ResearchPlan_4_0-4.0.pdf
333977 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
333977 RR_Budget_3_0-3.0.pdf
333977 RR_SubawardBudget30_3_0-3.0.pdf
333977 PHS398_ModularBudget_1_2-1.2.pdf
333977 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
333977 RR_SF424_2_0-2.0.pdf
333977 PHS398_CoverPageSupplement_5_0-5.0.pdf
333977 RR_OtherProjectInfo_1_4-1.4.pdf
333977 PerformanceSite_2_0-2.0.pdf
333977 RR_KeyPersonExpanded_2_0-2.0.pdf
333977 PHS398_ResearchPlan_4_0-4.0.pdf
333977 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
333977 RR_Budget_1_4-1.4.pdf
333977 RR_SubawardBudget30_1_4-1.4.pdf
333977 PHS398_ModularBudget_1_2-1.2.pdf
333977 PHS_AssignmentRequestForm_3_0-3.0.pdf
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