This National Institutes of Health R01 grant is offered to promote in vivo studies of stem cells in animal models and, if applicable, humans. The grant’s purpose is to better understand how embryonic stem cells (ESCs), adult stem cells, and induced pluripotent stem cells (iPSCs) function within developing or damaged tissues. It will support systematic profiling of genetic and epigenetic changes in stem cells and their microenvironment. Key areas include exploring ESC differentiation into specialized cell types, the role of adult stem cells in tissue regeneration and wound healing, and iPSC behavior at injury sites during therapy. This knowledge will enable the generation of iPSCs more closely resembling ESCs, ultimately ameliorating safety concerns related to incomplete differentiation and improper integration in stem cell therapies.
Opportunity ID: 217835
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-13-094 |
| Funding Opportunity Title: | Differentiation and Integration of Stem Cells (Embryonic and Induced-Pluripotent) Into Developing or Damaged Tissues (R01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.865 — Child Health and Human Development Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jan 28, 2013 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Sep 07, 2016 |
| Current Closing Date for Applications: | Sep 07, 2016 |
| Archive Date: | Oct 08, 2016 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | State governments City or township governments Native American tribal governments (Federally recognized) For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) County governments Special district governments Independent school districts Small businesses Private institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The primary focus of the FOA is to promote in vivo studies of stem cells in animal models and in humans (if applicable) to better understand how stem cells function within developing or damaged tissues. The areas of emphasis would include systematically profiling and cataloging changes at genetic and epigenetic levels that take place in stem cells and their microenvironment. The purpose is to gain in-depth knowledge of the mechanisms involved in: progressive differentiation of Embryonic Stem Cells (ESCs) into embryonic lineages, progenitor cells and specialized cell types; adult stem cells/progenitor cells during tissue regeneration and wound healing; and Induced Pluripotent Stem Cells (iPSCs) at the site of injury during stem cell therapy. Understanding the basic mechanisms and application of knowledge-based approaches would allow researchers to generate iPSCs that are more closely related to the ESCs at both genetic and epigenetic levels. Furthermore, it is expected that replicating developmental mechanisms would ameliorate the safety concerns associated with incomplete differentiation and improper integration of cells in damaged or diseased tissues during stem cell therapy. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-13-094.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 93.865 | ADOBE-FORMS-B2 | Adobe-Forms-B2 | PKG00162210 | May 05, 2013 | Sep 24, 2013 | View |
| 93.865 | FORMS-C | Use for due dates before May 25, 2016 | PKG00180647 | May 05, 2013 | May 07, 2016 | View |
| FORMS-D | Use for due dates on or after May 25, 2016 | PKG00222107 | Apr 17, 2016 | Sep 07, 2016 | View |
Package 1
Mandatory forms
217835 RR_SF424_1_2-1.2.pdf
217835 PerformanceSite_1_4-1.4.pdf
217835 RR_OtherProjectInfo_1_3-1.3.pdf
217835 RR_KeyPersonExpanded_1_2-1.2.pdf
217835 PHS398_CoverPageSupplement_1_4-1.4.pdf
217835 PHS398_ResearchPlan_1_3-1.3.pdf
217835 PHS398_Checklist_1_3-1.3.pdf
Optional forms
217835 RR_SubawardBudget30-1.2.pdf
217835 PHS398_ModularBudget_1_2-1.2.pdf
217835 RR_Budget-1.1.pdf
217835 PHS_CoverLetter_1_2-1.2.pdf
Package 2
Mandatory forms
217835 RR_SF424_2_0-2.0.pdf
217835 PHS398_ResearchPlan_2_0-2.0.pdf
217835 PHS398_CoverPageSupplement_2_0-2.0.pdf
217835 RR_KeyPersonExpanded_2_0-2.0.pdf
217835 RR_OtherProjectInfo_1_3-1.3.pdf
217835 PerformanceSite_2_0-2.0.pdf
Optional forms
217835 RR_SubawardBudget30_1_3-1.3.pdf
217835 PlannedReport-1.0.pdf
217835 PHS398_CumulativeInclusionReport-1.0.pdf
217835 PHS398_ModularBudget_1_2-1.2.pdf
217835 RR_Budget_1_3-1.3.pdf
Package 3
Mandatory forms
217835 RR_SF424_2_0-2.0.pdf
217835 PHS398_CoverPageSupplement_3_0-3.0.pdf
217835 RR_OtherProjectInfo_1_3-1.3.pdf
217835 PerformanceSite_2_0-2.0.pdf
217835 RR_KeyPersonExpanded_2_0-2.0.pdf
217835 PHS398_ResearchPlan_3_0-3.0.pdf
Optional forms
217835 RR_Budget_1_3-1.3.pdf
217835 RR_SubawardBudget30_1_3-1.3.pdf
217835 PHS398_ModularBudget_1_2-1.2.pdf
217835 PHS_Inclusion_Enrollment_Report-1.0.pdf
217835 PHS_AssignmentRequestForm-1.0.pdf
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