This grant is offered by a Health Research Department to fund studies investigating the complex mechanisms behind HIV-associated neurological disorders (HAND). Utilizing advanced methodologies, researchers are invited to propose projects employing induced microglia and cerebral organoids derived from human induced pluripotent stem cell (iPSC) lines. A primary focus is on understanding the critical comorbidity between HIV and various neural stimulants, including amphetamine, methamphetamine, cocaine, and nicotine. The research should delve into these interactions at both the single-cell and neural circuit levels, aiming to elucidate the neuropathophysiology of HAND. This initiative seeks to advance our knowledge of how neural stimulants exacerbate HIV-related neurological complications using innovative organoid modeling.
Opportunity ID: 334223
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DA-22-009 |
| Funding Opportunity Title: | Organoid Modeling of Neural Stimulants and HIV Comorbidity of Human Brain (R01- Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.279 — Drug Abuse and Addiction Research Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jun 17, 2021 |
| Last Updated Date: | Jun 17, 2021 |
| Original Closing Date for Applications: | Nov 17, 2021 |
| Current Closing Date for Applications: | Nov 17, 2021 |
| Archive Date: | Dec 23, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Special district governments Independent school districts Public housing authorities/Indian housing authorities For profit organizations other than small businesses Small businesses County governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) State governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) invites grant applications to study mechanisms underlying the neuropathophysiology of HIV-associated neurological disorders (HAND) using induced microglia and cerebral organoids generated from human derived induced pluripotent stem cell (iPSC) lines. Specific emphasis is on the comorbidity of HIV and neural stimulants, including amphetamine, methamphetamine, cocaine, and nicotine, studied at the single cell and neural circuits levels. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-22-009.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00267805 | Oct 17, 2021 | Jan 24, 2022 | View | |
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00269825 | Oct 28, 2021 | Nov 17, 2021 | View |
Package 1
Mandatory forms
334223 RR_SF424_2_0-2.0.pdf
334223 PHS398_CoverPageSupplement_5_0-5.0.pdf
334223 RR_OtherProjectInfo_1_4-1.4.pdf
334223 PerformanceSite_2_0-2.0.pdf
334223 RR_KeyPersonExpanded_2_0-2.0.pdf
334223 PHS398_ResearchPlan_4_0-4.0.pdf
334223 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
334223 RR_Budget_1_4-1.4.pdf
334223 RR_SubawardBudget30_1_4-1.4.pdf
334223 PHS398_ModularBudget_1_2-1.2.pdf
334223 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
334223 RR_SF424_5_0-5.0.pdf
334223 PHS398_CoverPageSupplement_5_0-5.0.pdf
334223 RR_OtherProjectInfo_1_4-1.4.pdf
334223 PerformanceSite_4_0-4.0.pdf
334223 RR_KeyPersonExpanded_4_0-4.0.pdf
334223 PHS398_ResearchPlan_4_0-4.0.pdf
334223 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
334223 RR_Budget_3_0-3.0.pdf
334223 RR_SubawardBudget30_3_0-3.0.pdf
334223 PHS398_ModularBudget_1_2-1.2.pdf
334223 PHS_AssignmentRequestForm_3_0-3.0.pdf
Share This Post, Choose Your Platform!
About the Author: osnqt
