This NIAAA grant is for investigating sensitivity and tolerance mechanisms critical to the development of alcohol use disorder (AUD). The National Institute on Alcohol Abuse and Alcoholism is offering this grant to support research aiming to develop hypotheses on cellular, molecular, or network mechanisms regulating alcohol sensitivity and tolerance. It also seeks to create quantitative models predicting tolerance development and the progression to AUD. Structured as a Phased Innovation (R21/R33) mechanism, the R21 phase allows for pilot studies or secondary data analysis. Transition to the R33 phase, enabling expanded hypothesis testing, is contingent upon achieving specific R21 milestones, evaluated by NIAAA program staff. Clinical trials are optional.
Opportunity ID: 334284
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-21-250 |
| Funding Opportunity Title: | Mechanisms of Alcohol Tolerance (R21/R33 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.273 — Alcohol Research Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jun 22, 2021 |
| Last Updated Date: | Jun 22, 2021 |
| Original Closing Date for Applications: | Sep 07, 2024 |
| Current Closing Date for Applications: | Sep 07, 2024 |
| Archive Date: | Oct 13, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | For profit organizations other than small businesses Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Small businesses State governments Special district governments Public and State controlled institutions of higher education City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) County governments Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This funding opportunity announcement (FOA) focuses on sensitivity and tolerance mechanisms underlying the development of alcohol use disorder. The intent of this FOA is to: (1) develop hypotheses about cellular, molecular or network mechanisms that regulate sensitivity and tolerance to alcohol, and (2) develop quantitative models to predict the development of tolerance and the progression to alcohol use disorder. These objectives will be accomplished with a Phased Innovation (R21/R33) mechanism, clinical trial optional, in which secondary data analysis or pilot studies can occur during the R21 phase, and research testing the hypotheses can be expanded in the R33 phase. The transition to the R33 phase will be determined by NIAAA program staff after evaluation of the achievement of specific milestones set for the R21 phase. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-21-250.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 334284 Full Announcement-PAR-21-250 -> PAR-21-250-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or before January 24, 2023 | PKG00270314 | Nov 16, 2021 | Jan 24, 2023 | View | |
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00267857 | Sep 16, 2021 | Jan 24, 2022 | View | |
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00278355 | Nov 14, 2022 | Sep 07, 2024 | View |
Package 1
Mandatory forms
334284 RR_SF424_5_0-5.0.pdf
334284 PHS398_CoverPageSupplement_5_0-5.0.pdf
334284 RR_OtherProjectInfo_1_4-1.4.pdf
334284 PerformanceSite_4_0-4.0.pdf
334284 RR_KeyPersonExpanded_4_0-4.0.pdf
334284 RR_Budget_3_0-3.0.pdf
334284 PHS398_ResearchPlan_4_0-4.0.pdf
334284 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
334284 RR_SubawardBudget30_3_0-3.0.pdf
334284 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
334284 RR_SF424_2_0-2.0.pdf
334284 PHS398_CoverPageSupplement_5_0-5.0.pdf
334284 RR_OtherProjectInfo_1_4-1.4.pdf
334284 PerformanceSite_2_0-2.0.pdf
334284 RR_KeyPersonExpanded_2_0-2.0.pdf
334284 RR_Budget_1_4-1.4.pdf
334284 PHS398_ResearchPlan_4_0-4.0.pdf
334284 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
334284 RR_SubawardBudget30_1_4-1.4.pdf
334284 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 3
Mandatory forms
334284 RR_SF424_5_0-5.0.pdf
334284 PHS398_CoverPageSupplement_5_0-5.0.pdf
334284 RR_OtherProjectInfo_1_4-1.4.pdf
334284 PerformanceSite_4_0-4.0.pdf
334284 RR_KeyPersonExpanded_4_0-4.0.pdf
334284 RR_Budget_3_0-3.0.pdf
334284 PHS398_ResearchPlan_5_0-5.0.pdf
334284 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
334284 RR_SubawardBudget30_3_0-3.0.pdf
334284 PHS_AssignmentRequestForm_3_0-3.0.pdf
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