The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) is offering this R01 Research Project Grant. This grant is for institutions and organizations to develop a comprehensive understanding of the natural history of disorders currently identified or potentially benefiting from newborn screening. The purpose is to define the sequence and timing of symptom onset and complications, creating a valuable resource for the field. Research will focus on genotype-phenotype correlations and identifying modifying factors to enhance understanding of clinical outcomes. The goal is to facilitate accurate diagnosis, understand genetic and clinical heterogeneity, identify underlying mechanisms, improve prevention and treatment, and provide crucial predictive information and support to children and their families. This funding targets multi-state consortia able to provide natural history information.
Opportunity ID: 54446
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HD-10-019 |
| Funding Opportunity Title: | Natural History of Disorders Identifiable by Newborn Screening (R01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | 2 |
| Assistance Listings: | 93.865 — Child Health and Human Development Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | May 07, 2010 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Aug 03, 2010 |
| Current Closing Date for Applications: | Aug 03, 2010 |
| Archive Date: | Sep 03, 2010 |
| Estimated Total Program Funding: | $2,000,000 |
| Award Ceiling: | $1,000,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Independent school districts City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education State governments County governments Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Purpose. This FOA issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, solicits Research Project Grant (R01) applications from institutions/ organizations that propose to develop a comprehensive understanding of the natural history of disorders that are currently identified by NBS or could potentially benefit from early identification by newborn screening. By defining the sequence and timing of the onset of symptoms and complications of a disorder, a valuable resource will be developed for the field.In addition, for some disorders, specific genotype-phenotype correlations may allow prediction of the clinical course, and for other disorders, identification of modifying genetic, epigenetic, or environmental factors will enhance an understanding of the clinical outcomes for an individual with such a condition. Comprehensive data on natural history will facilitate the field’s ability to: 1) accurately diagnose the disorder; 2) understand the genetic and clinical heterogeneity and phenotypic expression of the disorder; 3) identify underlying mechanisms related to basic defects; 4) potentially prevent, manage, and treat symptoms and complications of the disorder; and 5) provide children and their families with needed support and predictive information about the disorder.
Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism Funds Available and Anticipated Number of Awards. The NICHD intends to commit a total of approximately $2,000,000 to this FOA in FY11 to award up to 2 applications. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Budget and Project Period. An applicant may request a budget of up to five years and total costs of up to $1,000,000 in each of the project years to support multi-state consortia of screening programs that are able provide natural history information for one or more disorders. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-10-019.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
Grants Info
Grants Information Phone 301-435-0714 Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | Grants Info Grants Information Phone 301-435-0714 Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 93.865 | ADOBE-FORMS-B | Use for submissions intended for due dates of January 25, 2010 and beyond | PKG00018556 | Jul 03, 2010 | Aug 03, 2010 | View |
Package 1
Mandatory forms
54446 RR_SF424_1_2-1.2.pdf
54446 PerformanceSite_1_3-1.3.pdf
54446 RR_OtherProjectInfo_1_2-1.2.pdf
54446 RR_KeyPersonExpanded_1_2-1.2.pdf
54446 PHS398_CoverPageSupplement_1_4-1.4.pdf
54446 PHS398_ResearchPlan_1_3-1.3.pdf
54446 PHS398_Checklist_1_3-1.3.pdf
Optional forms
54446 PHS_CoverLetter_1_2-1.2.pdf
54446 PHS398_ModularBudget-1.1.pdf
54446 RR_Budget-1.1.pdf
54446 RR_SubawardBudget-1.2.pdf
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