The Human Islet Research Network (HIRN) is offering this cooperative agreement grant to expand the existing Human Pancreas Analysis Program (HPAP) by focusing on pancreata from tissue donors with Type 2 Diabetes (T2D) and related metabolic disorders. This grant is for the purpose of funding a specialized team to identify, collect, and intensively characterize primary pancreatic tissues from T2D patients and related islet dysfunction, as well as age-matched controls. The awarded team will be responsible for analyzing, organizing, and sharing the comprehensive data generated from these studies through the existing PANC DB open-access resource. This initiative contributes to HIRN’s overarching mission to advance translational research on human beta cell function and loss, developing strategies to protect and replace functional beta cell mass, specifically extending this vital work into the area of T2D.
Opportunity ID: 350703
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DK-25-002 |
| Funding Opportunity Title: | Single Source for continuation of the Human Pancreas Analysis Program for Type-2 Diabetes (HPAP-T2D) (U01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Food and Nutrition Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 24, 2023 |
| Last Updated Date: | Oct 24, 2023 |
| Original Closing Date for Applications: | Feb 28, 2024 |
| Current Closing Date for Applications: | Feb 28, 2024 |
| Archive Date: | Apr 04, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $2,000,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Notice of Funding Opportunity (NOFO) invites cooperative agreement applications to expand the operational scope of the existing Human Pancreas Analysis Program (HPAP) to the study of pancreata recovered from tissue donors with Type 2 Diabetes (T2D) and related metabolic disorders. This NOFO will support one team of investigators with combined expertise in human pancreas physiology and pathophysiology; collection, processing and multimodal analysis of human pancreatic tissues; and biological database building, curation and management, that will be tasked to: 1) identify, collect and intensively characterize primary pancreatic tissues from patients with T2D and related forms of islet dysfunction, as well as age-matched controls; and 2) analyze, organize and share the data resulting from the study of these tissues through use and expansion of the existing PANC DB open-access resource database. HPAP is a component of the Human Islet Research Network (HIRN), created in 2014 to support innovative and collaborative translational research to understand how human beta cells are lost in Type 1 Diabetes (T1D), and to find innovative strategies to protect and replace functional human beta cell mass. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-25-002.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 350703 Full Announcement-RFA-DK-25-002 -> RFA-DK-25-002-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00283591 | Jan 29, 2024 | Feb 28, 2024 | View |
Package 1
Mandatory forms
350703 RR_SF424_5_0-5.0.pdf
350703 PHS398_CoverPageSupplement_5_0-5.0.pdf
350703 RR_OtherProjectInfo_1_4-1.4.pdf
350703 PerformanceSite_4_0-4.0.pdf
350703 RR_KeyPersonExpanded_4_0-4.0.pdf
350703 PHS398_ResearchPlan_5_0-5.0.pdf
350703 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
350703 RR_Budget_3_0-3.0.pdf
350703 RR_SubawardBudget30_3_0-3.0.pdf
350703 PHS398_ModularBudget_1_2-1.2.pdf
350703 PHS_AssignmentRequestForm_3_0-3.0.pdf
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