This NIDCD grant is for advancing hearing and balance research by fostering the development, characterization, and reliable reproducibility of human auditory and vestibular organoids. The initiative encourages innovative methodologies and novel technologies to enhance the longevity and stability of these sensory organoid model systems. Proposals should focus on creating new tools for delivering genes, proteins, or molecules to ensure organoid expansion and long-term survival in a stable, reproducible manner. Subsequent characterization must demonstrate that organoid platforms accurately mimic native biological function. The grant highly encourages approaches that overcome current challenges and barriers to improve reproducibility and stability, especially those with breakthrough technologies utilizing human auditory and vestibular organoids. Studies involving animal organoids are permissible only if integrated with comparative human organoid research.
Opportunity ID: 350715
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAS-24-058 |
| Funding Opportunity Title: | Advancing Hearing and Balance Research Using Auditory and Vestibular Organoids (R01-Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.173 — Research Related to Deafness and Communication Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 25, 2023 |
| Last Updated Date: | Oct 25, 2023 |
| Original Closing Date for Applications: | May 07, 2024 |
| Current Closing Date for Applications: | May 07, 2024 |
| Archive Date: | Jun 12, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $499,999 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education Independent school districts State governments County governments Native American tribal governments (Federally recognized) Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities City or township governments For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Private institutions of higher education Small businesses Native American tribal organizations (other than Federally recognized tribal governments) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this NIDCD initiative is to encourage research in the development, characterization, and reproducibility/reliability of human auditory and vestibular organoids.Applications investigating animal organoids are allowable but only if accompanying comparative or other integrated companion studies with human organoids. Singular animal organoid studies alone are not responsive to this funding opportunity. This funding opportunity encourages innovative, reproducible, and novel methodologies and technologies that will drive the reproducibility and holistic longevity of hearing/balance sensory organoids as model systems. The development of novel tools to deliver genes, proteins, molecules, and synthetics that might lead to the successful expansion and longer-term survivability of organoid populations in a stable, reliable, and reproducible manner is highly encouraged. Subsequent characterization of the organoid platforms must be shown to mimic and recapitulate the native correlative biological function. Applications that provide approaches that remove current barriers and lessen challenges to improve current reproducibility and stability are highly encouraged. Applications that have breakthrough approaches and technologies using human auditory/vestibular organoids are highly encouraged. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAS-24-058.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 350715 Full Announcement-PAS-24-058 -> PAS-24-058-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00283598 | Jan 05, 2024 | May 07, 2024 | View |
Package 1
Mandatory forms
350715 RR_SF424_5_0-5.0.pdf
350715 PHS398_CoverPageSupplement_5_0-5.0.pdf
350715 RR_OtherProjectInfo_1_4-1.4.pdf
350715 PerformanceSite_4_0-4.0.pdf
350715 RR_KeyPersonExpanded_4_0-4.0.pdf
350715 PHS398_ResearchPlan_5_0-5.0.pdf
350715 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
350715 RR_Budget_3_0-3.0.pdf
350715 RR_SubawardBudget30_3_0-3.0.pdf
350715 PHS398_ModularBudget_1_2-1.2.pdf
350715 PHS_AssignmentRequestForm_3_0-3.0.pdf
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