The National Cancer Institute (NCI) and National Center for Complementary and Alternative Medicine (NCCAM) are offering this grant to characterize how microbially generated metabolites from dietary components affect host cell biology. This grant is for better understanding their molecular mechanisms, including effects on cell proliferative/apoptotic responses, cytokine production, inflammation, and immunomodulation. It also encourages human intervention studies to identify inter-individual variability across racial and ethnic groups in bacterial metabolite production and their efficacy in cancer prevention. This research is crucial for comprehending the role of diet in cancer etiology, prevention, and health disparities, helping identify who benefits from specific dietary recommendations. The program aims to foster interdisciplinary collaborations, requiring multiple principal investigators with diverse expertise.
Opportunity ID: 54841
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-10-208 |
| Funding Opportunity Title: | The Role of Microbial Metabolites in Cancer Prevention and Etiology (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.213 — Research and Training in Complementary and Alternative Medicine |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | May 27, 2010 |
| Last Updated Date: | Mar 15, 2011 |
| Original Closing Date for Applications: | Nov 15, 2012 |
| Current Closing Date for Applications: | Mar 15, 2011 |
| Archive Date: | Apr 15, 2011 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education For profit organizations other than small businesses Small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Purpose. This Funding Opportunity Announcement (FOA) issued by the National Cancer Institute (NCI), and the National Center for Complementary and Alternative Medicine, (NCCAM), at the National Institutes of Health, encourages the submission of grant applications that characterize the effects of microbially generated metabolites of dietary components on host cell biology. Specifically, this FOA seeks to characterize microbially generated metabolites and better understand their molecular mechanisms of action that affect host cell proliferative/apoptotic responses, cytokine production, inflammatory and immunomodulatory effects. This FOA will also encourage the conduct of human intervention studies that identify inter-individual variability among various racial and ethnic groups in the production of bacterial metabolites and determine their efficacy in cancer prevention. This research is necessary to better understand the role of dietary components in cancer etiology, prevention, and cancer health disparities to identify who might benefit from specific dietary recommendations and who might be placed at risk. One of the goals of this program will be to facilitate interdisciplinary collaborations among scientists engaged in nutrition, cancer prevention, cancer cell biology research, and cancer disparities research with those conducting studies with gut microorganisms. All applications must include multiple principle investigators with different areas of expertise such as microbiology, nutrition, cancer biology, analytical chemistry, or genetics. In addition, all investigators will be required to attend annual meetings with NIH personnel. Investigators may use either clinical or preclinical approaches. Mechanism of Support. This FOA will utilize the NIH U01 cooperative agreement mechanism. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-10-208.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| This funding opportunity is being closed and archived, and has been reissued as http://grants.nih.gov/grants/guide/pa-files/PAR-11-152.html. | Mar 15, 2011 | |
| Mar 15, 2011 |
DISPLAYING: Synopsis 2
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-10-208 |
| Funding Opportunity Title: | The Role of Microbial Metabolites in Cancer Prevention and Etiology (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.213 — Research and Training in Complementary and Alternative Medicine |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | May 27, 2010 |
| Last Updated Date: | Mar 15, 2011 |
| Original Closing Date for Applications: | Nov 15, 2012 |
| Current Closing Date for Applications: | Mar 15, 2011 |
| Archive Date: | Apr 15, 2011 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education For profit organizations other than small businesses Small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Purpose. This Funding Opportunity Announcement (FOA) issued by the National Cancer Institute (NCI), and the National Center for Complementary and Alternative Medicine, (NCCAM), at the National Institutes of Health, encourages the submission of grant applications that characterize the effects of microbially generated metabolites of dietary components on host cell biology. Specifically, this FOA seeks to characterize microbially generated metabolites and better understand their molecular mechanisms of action that affect host cell proliferative/apoptotic responses, cytokine production, inflammatory and immunomodulatory effects. This FOA will also encourage the conduct of human intervention studies that identify inter-individual variability among various racial and ethnic groups in the production of bacterial metabolites and determine their efficacy in cancer prevention. This research is necessary to better understand the role of dietary components in cancer etiology, prevention, and cancer health disparities to identify who might benefit from specific dietary recommendations and who might be placed at risk. One of the goals of this program will be to facilitate interdisciplinary collaborations among scientists engaged in nutrition, cancer prevention, cancer cell biology research, and cancer disparities research with those conducting studies with gut microorganisms. All applications must include multiple principle investigators with different areas of expertise such as microbiology, nutrition, cancer biology, analytical chemistry, or genetics. In addition, all investigators will be required to attend annual meetings with NIH personnel. Investigators may use either clinical or preclinical approaches. Mechanism of Support. This FOA will utilize the NIH U01 cooperative agreement mechanism. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-10-208.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
DISPLAYING: Synopsis 1
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-10-208 |
| Funding Opportunity Title: | The Role of Microbial Metabolites in Cancer Prevention and Etiology (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.213 — Research and Training in Complementary and Alternative Medicine |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Mar 15, 2011 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | Nov 15, 2012 |
| Archive Date: | Dec 16, 2012 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | State governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Purpose. This Funding Opportunity Announcement (FOA) issued by the National Cancer Institute (NCI), and the National Center for Complementary and Alternative Medicine, (NCCAM), at the National Institutes of Health, encourages the submission of grant applications that characterize the effects of microbially generated metabolites of dietary components on host cell biology. Specifically, this FOA seeks to characterize microbially generated metabolites and better understand their molecular mechanisms of action that affect host cell proliferative/apoptotic responses, cytokine production, inflammatory and immunomodulatory effects. This FOA will also encourage the conduct of human intervention studies that identify inter-individual variability among various racial and ethnic groups in the production of bacterial metabolites and determine their efficacy in cancer prevention. This research is necessary to better understand the role of dietary components in cancer etiology, prevention, and cancer health disparities to identify who might benefit from specific dietary recommendations and who might be placed at risk. One of the goals of this program will be to facilitate interdisciplinary collaborations among scientists engaged in nutrition, cancer prevention, cancer cell biology research, and cancer disparities research with those conducting studies with gut microorganisms. All applications must include multiple principle investigators with different areas of expertise such as microbiology, nutrition, cancer biology, analytical chemistry, or genetics. In addition, all investigators will be required to attend annual meetings with NIH personnel. Investigators may use either clinical or preclinical approaches. Mechanism of Support. This FOA will utilize the NIH U01 cooperative agreement mechanism. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-10-208.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
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