This National Institutes of Health grant is for supporting rigorous, hypothesis-driven research aimed at understanding the complex dysregulation of transposable elements (TEs) and their significant contributions to the pathogenesis of Alzheimer’s disease (AD), Alzheimer’s disease-related dementias (ADRD), and the broader aging process. This funding opportunity particularly encourages applications investigating the direct causal effects of TE activation within these disease states and in aging. Furthermore, it seeks proposals that model potential therapeutic interventions targeting TEs. The overarching purpose of this grant is to facilitate the scientific field’s crucial transition from purely observational discoveries towards a more profound mechanistic understanding of TE function and their intricate regulation in neurological health and decline.
Opportunity ID: 334714
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AG-22-021 |
| Funding Opportunity Title: | Elucidating the Roles of Transposable Elements in AD/ADRD and Aging (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.866 — Aging Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jul 14, 2021 |
| Last Updated Date: | Jul 14, 2021 |
| Original Closing Date for Applications: | Nov 02, 2021 |
| Current Closing Date for Applications: | Nov 02, 2021 |
| Archive Date: | Dec 08, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | For profit organizations other than small businesses City or township governments Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Special district governments Independent school districts Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) County governments Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education State governments Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The goal of this Funding Opportunity Announcement (FOA) is to support hypothesis-driven research to gain an understanding of the dysregulation of transposable elements (TE) and their contributions to Alzheimer’s disease (AD) and Alzheimer’s disease-related dementias (ADRD) and aging. This FOA encourages applications that investigate causal effects of TE activation in disease and aging and applications that model therapeutic interventions to facilitate the transition of the field from observational discovery towards a deeper mechanistic understanding of the function and regulation of TEs. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-22-021.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00268200 | Oct 02, 2021 | Jan 24, 2022 | View | |
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00269821 | Oct 28, 2021 | Nov 02, 2021 | View |
Package 1
Mandatory forms
334714 RR_SF424_2_0-2.0.pdf
334714 PHS398_CoverPageSupplement_5_0-5.0.pdf
334714 RR_OtherProjectInfo_1_4-1.4.pdf
334714 PerformanceSite_2_0-2.0.pdf
334714 RR_KeyPersonExpanded_2_0-2.0.pdf
334714 PHS398_ResearchPlan_4_0-4.0.pdf
334714 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
334714 RR_Budget_1_4-1.4.pdf
334714 RR_SubawardBudget30_1_4-1.4.pdf
334714 PHS398_ModularBudget_1_2-1.2.pdf
334714 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
334714 RR_SF424_5_0-5.0.pdf
334714 PHS398_CoverPageSupplement_5_0-5.0.pdf
334714 RR_OtherProjectInfo_1_4-1.4.pdf
334714 PerformanceSite_4_0-4.0.pdf
334714 RR_KeyPersonExpanded_4_0-4.0.pdf
334714 PHS398_ResearchPlan_4_0-4.0.pdf
334714 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
334714 RR_Budget_3_0-3.0.pdf
334714 RR_SubawardBudget30_3_0-3.0.pdf
334714 PHS398_ModularBudget_1_2-1.2.pdf
334714 PHS_AssignmentRequestForm_3_0-3.0.pdf
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