This grant is for advancing novel and practical research methods to enhance the prevention and management of symptoms in chronic illness. It seeks to update traditional randomized control trial (RCT) designs, aiming for more effective clinical outcomes by identifying optimal treatment strategies. The grant addresses challenges like varied patient responses, retention, and adherence. Promising approaches, such as Sequential Multiple Assignment Randomization Trials (SMART) and Multiphase Optimization Strategy (MOST), are encouraged. These methods enable adaptive, tailored interventions mirroring clinical practice, allowing re-evaluation and adjustment based on individual progress, ultimately improving symptom burden and patient outcomes.
Opportunity ID: 228549
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-13-166 |
| Funding Opportunity Title: | Innovative Research Methods: Prevention and Management of Symptoms in Chronic Illness (R15) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.361 — Nursing Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Mar 29, 2013 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | May 07, 2016 |
| Current Closing Date for Applications: | May 07, 2016 |
| Archive Date: | Jun 07, 2016 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $300,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Private institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs) ; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This funding opportunity seeks to update the randomized control trial (RCT) design using novel research methods that are practical, innovative, and hold promise for producing more effective outcomes. Novel clinical research designs, applied to symptom management trials, may identify those treatment strategies that best alter the course of symptom burden in chronic illness by addressing the issues of varied treatment responses across patients, subject retention, and adherence to treatment regimens. For example, sequential multiple assignment randomization trials (SMART) design have been used successfully to develop dynamic treatment regimens for alcohol, depression and HIV infection but are not widely used in symptom management trials. The approach is pragmatic in that it mimics clinical practice by allowing a re-evaluation of treatment options based on an individuals progress towards treatment goals. The levels or inclusion of intervention components are tailored in response to individual characteristics or progress toward a treatment goal. Subjects may be randomly assigned several times to varying amounts and types of intervention components based on predetermined decision rules. This sequential decision making process allows for the initial intervention to be adapted and provides subjects with options for achieving a favorable outcome. A Multiphase optimization strategy (MOST) could also prove useful when applied to symptom management trials. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PA-13-166.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| ADOBE-FORMS-B2 | Adobe-Forms-B2 | PKG00171755 | May 25, 2013 | Sep 24, 2013 | View | |
| FORMS-C | Use for due dates after 9/24/2013 | PKG00181475 | Sep 25, 2013 | May 07, 2016 | View |
Package 1
Mandatory forms
228549 RR_SF424_1_2-1.2.pdf
228549 PerformanceSite_1_4-1.4.pdf
228549 RR_OtherProjectInfo_1_3-1.3.pdf
228549 RR_KeyPersonExpanded_1_2-1.2.pdf
228549 PHS398_CoverPageSupplement_1_4-1.4.pdf
228549 PHS398_ResearchPlan_1_3-1.3.pdf
228549 PHS398_Checklist_1_3-1.3.pdf
Optional forms
228549 RR_SubawardBudget30-1.2.pdf
228549 PHS398_ModularBudget_1_2-1.2.pdf
228549 RR_Budget-1.1.pdf
228549 PHS_CoverLetter_1_2-1.2.pdf
Package 2
Mandatory forms
228549 RR_SF424_2_0-2.0.pdf
228549 PHS398_ResearchPlan_2_0-2.0.pdf
228549 PHS398_CoverPageSupplement_2_0-2.0.pdf
228549 RR_KeyPersonExpanded_2_0-2.0.pdf
228549 RR_OtherProjectInfo_1_3-1.3.pdf
228549 PerformanceSite_2_0-2.0.pdf
Optional forms
228549 RR_SubawardBudget30_1_3-1.3.pdf
228549 PlannedReport-1.0.pdf
228549 PHS398_CumulativeInclusionReport-1.0.pdf
228549 PHS398_ModularBudget_1_2-1.2.pdf
228549 RR_Budget_1_3-1.3.pdf
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