This grant is for developing and applying novel research methods to improve randomized controlled trial (RCT) designs for managing symptoms in chronic illnesses. The aim is to identify more effective treatment strategies by addressing common challenges such as varied patient responses, subject retention, and adherence to regimens. It encourages the use of pragmatic approaches like Sequential Multiple Assignment Randomization Trials (SMART), which allow for dynamic treatment adjustments based on individual progress, mirroring clinical practice. While proven successful in other health areas, these innovative designs are currently underutilized in symptom management research. The goal is to produce more effective outcomes and significantly alter the course of symptom burden.
Opportunity ID: 228550
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-13-167 |
| Funding Opportunity Title: | Innovative Research Methods: Prevention and Management of Symptoms in Chronic Illness (R21) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.361 — Nursing Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Mar 29, 2013 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | May 07, 2016 |
| Current Closing Date for Applications: | May 07, 2016 |
| Archive Date: | Jun 07, 2016 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $200,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal governments (Federally recognized) Private institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments For profit organizations other than small businesses Public and State controlled institutions of higher education Independent school districts State governments County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This funding opportunity seeks to update the randomized control trial (RCT) design using novel research methods that are practical, innovative, and hold promise for producing more effective outcomes. Novel clinical research designs, applied to symptom management trials, may identify those treatment strategies that best alter the course of symptom burden in chronic illness by addressing the issues of varied treatment responses across patients, subject retention, and adherence to treatment regimens. For example, sequential multiple assignment randomization trials (SMART) design have been used successfully to develop dynamic treatment regimens for alcohol, depression and HIV infection but are not widely used in symptom management trials. The approach is pragmatic in that it mimics clinical practice by allowing a re-evaluation of treatment options based on an individuals progress towards treatment goals. The levels or inclusion of intervention components are tailored in response to individual characteristics or progress toward a treatment goal. Subjects may be randomly assigned several times to varying amounts and types of intervention components based on predetermined decision rules. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PA-13-167.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| ADOBE-FORMS-B2 | Adobe-Forms-B2 | PKG00171757 | May 05, 2013 | Sep 24, 2013 | View | |
| FORMS-C | Use for due dates after 9/24/2013 | PKG00181627 | Sep 16, 2013 | May 07, 2016 | View |
Package 1
Mandatory forms
228550 RR_SF424_1_2-1.2.pdf
228550 PerformanceSite_1_4-1.4.pdf
228550 RR_OtherProjectInfo_1_3-1.3.pdf
228550 RR_KeyPersonExpanded_1_2-1.2.pdf
228550 PHS398_CoverPageSupplement_1_4-1.4.pdf
228550 PHS398_ResearchPlan_1_3-1.3.pdf
228550 PHS398_Checklist_1_3-1.3.pdf
Optional forms
228550 RR_SubawardBudget30-1.2.pdf
228550 PHS398_ModularBudget_1_2-1.2.pdf
228550 RR_Budget-1.1.pdf
228550 PHS_CoverLetter_1_2-1.2.pdf
Package 2
Mandatory forms
228550 RR_SF424_2_0-2.0.pdf
228550 PHS398_ResearchPlan_2_0-2.0.pdf
228550 PHS398_CoverPageSupplement_2_0-2.0.pdf
228550 RR_KeyPersonExpanded_2_0-2.0.pdf
228550 RR_OtherProjectInfo_1_3-1.3.pdf
228550 PerformanceSite_2_0-2.0.pdf
Optional forms
228550 RR_SubawardBudget30_1_3-1.3.pdf
228550 PlannedReport-1.0.pdf
228550 PHS398_CumulativeInclusionReport-1.0.pdf
228550 PHS398_ModularBudget_1_2-1.2.pdf
228550 RR_Budget_1_3-1.3.pdf
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