NCATS is offering this grant to facilitate rare diseases research, enabling efficient movement toward clinical trials across multiple rare diseases. This grant is for supporting basket clinical trials that target shared molecular etiologies in more than one rare disease. The initiative also aims to identify and overcome challenges in adapting the oncology basket trial model to the rare disease context. Projects funded by this NOFO will require expertise in conducting clinical trials for rare diseases. Applicants are encouraged to collaborate with clinical investigators at academic institutions. Strong preference will be given to projects involving investigators from the Rare Disease Clinical Research Network (RDCRN) focusing on diseases currently under study within the RDCRN.
Opportunity ID: 351265
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-TR-24-001 |
| Funding Opportunity Title: | Basket Clinical Trials of Drugs Targeting Shared Molecular Etiologies in Multiple Rare Diseases (U44 Clinical Trial Required) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.350 — National Center for Advancing Translational Sciences |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 01, 2023 |
| Last Updated Date: | Dec 01, 2023 |
| Original Closing Date for Applications: | Mar 15, 2024 |
| Current Closing Date for Applications: | Mar 15, 2024 |
| Archive Date: | Apr 20, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $306,872 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, may be allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | NCATS seeks to facilitate rare diseases research by enabling efficient and effective movement toward clinical trials in multiple rare diseases. The purpose of this NOFO is to provide support for basket clinical trials of drugs targeting shared molecular etiologies in more than one rare disease, and in the process to identify and overcome challenges in adapting the oncology basket trial model to rare diseases. Projects proposed for this NOFO will require individuals with expertise in carrying out clinical trials in rare diseases. Applicants are expected to collaborate with clinical investigators at academic institutions. Projects involving clinical investigators who are part of the Rare Disease Clinical Research Network (RDCRN) and which focus on diseases under study in the RDCRN are strongly encouraged. See https://www.rarediseasesnetwork.org/ for additional information. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-TR-24-001.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 351265 Full Announcement-RFA-TR-24-001 -> RFA-TR-24-001-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00283988 | Dec 04, 2023 | Mar 15, 2024 | View |
Package 1
Mandatory forms
351265 RR_SF424_5_0-5.0.pdf
351265 PHS398_CoverPageSupplement_5_0-5.0.pdf
351265 RR_OtherProjectInfo_1_4-1.4.pdf
351265 PerformanceSite_4_0-4.0.pdf
351265 RR_KeyPersonExpanded_4_0-4.0.pdf
351265 RR_Budget_3_0-3.0.pdf
351265 PHS398_ResearchPlan_5_0-5.0.pdf
351265 SBIR_STTR_Information_3_0-3.0.pdf
351265 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
351265 RR_SubawardBudget30_3_0-3.0.pdf
351265 PHS_AssignmentRequestForm_3_0-3.0.pdf
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