This grant is for conducting preclinical and clinical research to explore the role of microbially generated metabolites in cancer prevention and progression. It aims to uncover the molecular mechanisms involved, such as effects on cell proliferation, apoptosis, inflammation, and immune modulation. A key focus is understanding the variability in metabolite production and its impact across diverse racial and ethnic groups, which is crucial for tailoring dietary recommendations. The research seeks to identify early markers and factors influencing individual responses to diet, addressing why dietary interventions yield inconsistent results. This initiative encourages interdisciplinary collaboration among experts in cancer biology, microbiology, nutrition, and genetics to foster comprehensive studies and facilitate the exchange of new findings and methodologies.
Opportunity ID: 229273
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-13-159 |
| Funding Opportunity Title: | The Role of Microbial Metabolites in Cancer Prevention and Etiology (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.393 — Cancer Cause and Prevention Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Apr 04, 2013 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Nov 14, 2014 |
| Current Closing Date for Applications: | Nov 14, 2014 |
| Archive Date: | Dec 15, 2014 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal governments (Federally recognized) City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments County governments State governments Public housing authorities/Indian housing authorities Private institutions of higher education Small businesses Independent school districts Public and State controlled institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) encourages preclinical and clinical research that will describe the effect of microbially generated metabolites in cancer prevention/ progression and the molecular mechanisms underlying these effects: proliferative/apoptotic responses, cytokine production, inflammatory and immunomodulatory effects locally and/or distant. This FOA encourages pre-clinical and clinical studies that will describe the variability in the bacterial metabolites production and their contribution to cancer prevention/promotion among various racial and ethnic groups. Due to inconsistent responses to dietary interventions, this research is necessary to identify who might benefit from specific dietary recommend ations and who might be placed at risk. It is important to identify the factors that contribute to differences in response to foods and food components and to identify early markers that will identify those who will receive maximum benefits from dietary change. As these are complex questions this program will facilitate interdisciplinary collaborations among scientists engaged in research in cancer prevention and microbiology, nutrition, cancer cell biology, and cancer disparities. To achieve this goal all applications are encouraged to include multiple Program Director(s)/Principal Investigator(s) with expertise in cancer biology, microbiology, nutrition, analytical chemistry or genetics. Investigations may use either clinical or preclinical approaches. All awardees are expected to attend an annual meeting with NIH personnel to report new findings and coordinate the exchange of new information and methodologies with interested colleagues and to promote collaboration. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-13-159.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| ADOBE-FORMS-B2 | Adobe-Forms-B2 | PKG00172430 | Oct 14, 2013 | Oct 14, 2013 | View | |
| FORMS-C | Forms-C | PKG00181011 | Oct 14, 2013 | Nov 14, 2014 | View |
Package 1
Mandatory forms
229273 RR_SF424_1_2-1.2.pdf
229273 PerformanceSite_1_4-1.4.pdf
229273 RR_OtherProjectInfo_1_3-1.3.pdf
229273 RR_KeyPersonExpanded_1_2-1.2.pdf
229273 PHS398_CoverPageSupplement_1_4-1.4.pdf
229273 PHS398_ResearchPlan_1_3-1.3.pdf
229273 PHS398_Checklist_1_3-1.3.pdf
Optional forms
229273 RR_SubawardBudget30-1.2.pdf
229273 PHS398_ModularBudget_1_2-1.2.pdf
229273 RR_Budget-1.1.pdf
229273 PHS_CoverLetter_1_2-1.2.pdf
Package 2
Mandatory forms
229273 RR_SF424_2_0-2.0.pdf
229273 PHS398_ResearchPlan_2_0-2.0.pdf
229273 PHS398_CoverPageSupplement_2_0-2.0.pdf
229273 RR_KeyPersonExpanded_2_0-2.0.pdf
229273 RR_OtherProjectInfo_1_3-1.3.pdf
229273 PerformanceSite_2_0-2.0.pdf
Optional forms
229273 RR_SubawardBudget30_1_3-1.3.pdf
229273 PlannedReport-1.0.pdf
229273 PHS398_CumulativeInclusionReport-1.0.pdf
229273 PHS398_ModularBudget_1_2-1.2.pdf
229273 RR_Budget_1_3-1.3.pdf
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