This NIH grant is for MorPhiC Phase 1 Data Production Research and Development Centers. The grant aims to establish the new ‘Molecular Phenotypes of Null Alleles in Cells’ (MorPhiC) program. Its long-term goal is to create a comprehensive, publicly accessible catalog of molecular and cellular phenotypes for null alleles across all human genes, utilizing in vitro multicellular systems. Phase 1 will focus on optimizing methods for generating null alleles and measuring their phenotypic effects in a subset of 1000 protein-coding genes. It will also assess scaling limitations, develop common data formats, and define use cases for the catalog. Successful applicants will develop diverse systems and assays, exploring and comparing innovative approaches to efficiently produce high-quality MorPhiC data at scale, ensuring its maximum informativeness for the biomedical community.
Opportunity ID: 335166
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HG-21-029 |
| Funding Opportunity Title: | Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Phase 1: Data Production Research and Development Centers (UM1)(Clinical trials not allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.172 — Human Genome Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 06, 2021 |
| Last Updated Date: | Aug 06, 2021 |
| Original Closing Date for Applications: | Nov 01, 2021 |
| Current Closing Date for Applications: | Nov 01, 2021 |
| Archive Date: | Dec 07, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Native American tribal governments (Federally recognized) Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Small businesses Private institutions of higher education Independent school districts City or township governments Public and State controlled institutions of higher education For profit organizations other than small businesses County governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This FOA is one of three issued to create a new program called “Molecular Phenotypes of Null Alleles in Cells (MorPhiC)”. The long-term goal of MorPhiC is to develop a consistent catalog of molecular and cellular phenotypes for null alleles for every human gene, using in vitro multicellular systems. The catalog will be made available for broad use by the biomedical community. The program will start with a Phase 1 to optimize available methods to create null alleles and measure their phenotypic effects in a target subset of 1000 protein coding genes across the program. Phase I will also assess the scale limitations of such methods, develop common data formats, and establish use cases for this catalog. This specific FOA seeks applications for MorPhiC Data Production Research and Development Centers, which will develop diverse systems and assays and explore and compare approaches to produce MorPhiC data at scale, and to maximize its informativeness. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-21-029.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00268493 | Oct 01, 2021 | Jan 24, 2022 | View |
Package 1
Mandatory forms
335166 RR_SF424_2_0-2.0.pdf
335166 PHS398_CoverPageSupplement_5_0-5.0.pdf
335166 RR_OtherProjectInfo_1_4-1.4.pdf
335166 PerformanceSite_2_0-2.0.pdf
335166 RR_KeyPersonExpanded_2_0-2.0.pdf
335166 RR_Budget_1_4-1.4.pdf
335166 PHS398_ResearchPlan_4_0-4.0.pdf
335166 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
335166 RR_SubawardBudget30_1_4-1.4.pdf
335166 PHS_AssignmentRequestForm_3_0-3.0.pdf
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