This grant is for research deciphering the cellular and molecular mechanisms underlying temporomandibular joint disorders (TMJD) pain and tissue dysfunction. Utilizing single-cell omics approaches, the initiative aims to uncover how TMJD develops and progresses, alongside understanding mechanisms promoting joint resolution and homeostasis. Successful projects will identify specific cell populations and their effector pathways within TMJD target tissues like synovial fluid, muscle, or skin. These findings are critical for developing molecular disease classifiers for patient stratification, discovering new diagnostic, prognostic, and predictive biomarkers, and ultimately identifying novel therapeutic targets. The overall goal is to advance understanding and treatment strategies for TMJD.
Opportunity ID: 335290
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DE-22-005 |
| Funding Opportunity Title: | Feasibility Studies that Explore Healthy and Diseased Temporomandibular Joints (TMJ) using Single Cell Multi-Omic Analyses (UH2/UH3 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.121 — Oral Diseases and Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 12, 2021 |
| Last Updated Date: | Aug 12, 2021 |
| Original Closing Date for Applications: | Nov 10, 2021 |
| Current Closing Date for Applications: | Nov 10, 2021 |
| Archive Date: | Dec 16, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal governments (Federally recognized) State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Independent school districts For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) County governments Special district governments Private institutions of higher education Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The goal of this initiative is to encourage research focused on deciphering the cellular and molecular mechanisms underpinning temporomandibular joint disorders (TMJD) pain and tissue dysfunction using single-cell omics approaches. Delineation of cellular and molecular mechanisms that mediate TMJD resolution and homeostasis are also desired. Identification of cell populations and their effector pathways, in TMJD target tissue (e.g. synovial fluid, muscle, skin), as 1) molecular disease classifiers allowing for patient stratification, 2) diagnostic, prognostic, and/or predictive biomarkers, and/or 3) novel therapeutic targets are desired outcomes of this initiative. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DE-22-005.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00268546 | Oct 10, 2021 | Jan 24, 2022 | View |
Package 1
Mandatory forms
335290 RR_SF424_2_0-2.0.pdf
335290 PHS398_CoverPageSupplement_5_0-5.0.pdf
335290 RR_OtherProjectInfo_1_4-1.4.pdf
335290 PerformanceSite_2_0-2.0.pdf
335290 RR_KeyPersonExpanded_2_0-2.0.pdf
335290 RR_Budget_1_4-1.4.pdf
335290 PHS398_ResearchPlan_4_0-4.0.pdf
335290 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
335290 RR_SubawardBudget30_1_4-1.4.pdf
335290 PHS_AssignmentRequestForm_3_0-3.0.pdf
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