This grant, Assessing Immune Memory (AIM), is for developing a platform to predict vaccine durability, crucial for military service members’ protection against communicable diseases and biothreats. Many existing vaccines lack long-term effectiveness, and current understanding of immune memory mechanisms, essential for lasting protection, is limited. It is currently challenging to predict vaccine efficacy from early responses due to a lack of insights into the complex cellular processes that establish durable immunity. The AIM grant seeks to address this critical gap by supporting research that fosters a systems-level view of host responses to vaccination, ultimately enabling better prediction of vaccine longevity and enhancing prophylactic options.
Opportunity ID: 335379
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | HR001121S0037 |
| Funding Opportunity Title: | Assessing Immune Memory (AIM) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement Other Procurement Contract |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 12.910 — Research and Technology Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Aug 20, 2021 |
| Last Updated Date: | Sep 07, 2021 |
| Original Closing Date for Applications: | Oct 26, 2021 See Full Announcement for details. |
| Current Closing Date for Applications: | Oct 26, 2021 See Full Announcement for details. |
| Archive Date: | Nov 25, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | All responsible sources capable of satisfying the Government’s needs may submit a proposal that shall be considered by DARPA. See the Eligibility Information section of the BAA for more information. |
Additional Information
| Agency Name: | DARPA – Biological Technologies Office |
| Description: | Military service members rely on effective vaccination for the prevention of communicable disease as well as to guard against biothreat exposure. Many current vaccines lack durability (i.e., do not provide effective protection over long periods of time), and there are multiple pathogens and threats that lack prophylactic options altogether. It is currently impossible to predict vaccine durability from early response profiles, largely owing to ignorance of mechanisms underlying immune memory as well as an inability to measure the cellular contributors that invoke long-lasting immune protection. Formation of immune memory is a complex physiological process characterized by a diverse array of cellular interactions and signaling processes. AIM seeks to develop a platform capability to predict immune memory informed by a systems-level view of the host response to vaccination and its mechanisms. |
| Link to Additional Information: | SAM.gov Contract Opportunities |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
BAA Coordinator
AIM@darpa.mil Email:AIM@darpa.mil |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Extend proposal abstract submission deadline. | Sep 07, 2021 | |
| Aug 20, 2021 |
DISPLAYING: Synopsis 2
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | HR001121S0037 |
| Funding Opportunity Title: | Assessing Immune Memory (AIM) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement Other Procurement Contract |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 12.910 — Research and Technology Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Aug 20, 2021 |
| Last Updated Date: | Sep 07, 2021 |
| Original Closing Date for Applications: | Oct 26, 2021 See Full Announcement for details. |
| Current Closing Date for Applications: | Oct 26, 2021 See Full Announcement for details. |
| Archive Date: | Nov 25, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | All responsible sources capable of satisfying the Government’s needs may submit a proposal that shall be considered by DARPA. See the Eligibility Information section of the BAA for more information. |
Additional Information
| Agency Name: | DARPA – Biological Technologies Office |
| Description: | Military service members rely on effective vaccination for the prevention of communicable disease as well as to guard against biothreat exposure. Many current vaccines lack durability (i.e., do not provide effective protection over long periods of time), and there are multiple pathogens and threats that lack prophylactic options altogether. It is currently impossible to predict vaccine durability from early response profiles, largely owing to ignorance of mechanisms underlying immune memory as well as an inability to measure the cellular contributors that invoke long-lasting immune protection. Formation of immune memory is a complex physiological process characterized by a diverse array of cellular interactions and signaling processes. AIM seeks to develop a platform capability to predict immune memory informed by a systems-level view of the host response to vaccination and its mechanisms. |
| Link to Additional Information: | SAM.gov Contract Opportunities |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
BAA Coordinator
AIM@darpa.mil Email:AIM@darpa.mil |
DISPLAYING: Synopsis 1
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | HR001121S0037 |
| Funding Opportunity Title: | Assessing Immune Memory (AIM) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement Other Procurement Contract |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 12.910 — Research and Technology Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 20, 2021 |
| Last Updated Date: | Aug 20, 2021 |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | Oct 26, 2021 See Full Announcement for details. |
| Archive Date: | Nov 25, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | All responsible sources capable of satisfying the Government’s needs may submit a proposal that shall be considered by DARPA. See the Eligibility Information section of the BAA for more information. |
Additional Information
| Agency Name: | DARPA – Biological Technologies Office |
| Description: | Military service members rely on effective vaccination for the prevention of communicable disease as well as to guard against biothreat exposure. Many current vaccines lack durability (i.e., do not provide effective protection over long periods of time), and there are multiple pathogens and threats that lack prophylactic options altogether. It is currently impossible to predict vaccine durability from early response profiles, largely owing to ignorance of mechanisms underlying immune memory as well as an inability to measure the cellular contributors that invoke long-lasting immune protection. Formation of immune memory is a complex physiological process characterized by a diverse array of cellular interactions and signaling processes. AIM seeks to develop a platform capability to predict immune memory informed by a systems-level view of the host response to vaccination and its mechanisms. |
| Link to Additional Information: | SAM.gov Contract Opportunities |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
BAA Coordinator
AIM@darpa.mil Email:AIM@darpa.mil |
Related Documents
Folder 335379 Full Announcement-HR001121S0037 -> Attachment_1_-_HR001121S0037_-_Proposal_Summary_Slides_Template.pdf
Folder 335379 Full Announcement-HR001121S0037 -> Attachment_2_-_HR001121S0037_-_Cost_Proposal_Spreadsheet.pdf
Folder 335379 Full Announcement-HR001121S0037 -> HR001121S0037.pdf
Folder 335379 Revised Full Announcement-HR001121S0037-Amendment-01 -> HR001121S0037-Amendment-01.pdf
Packages
| Agency Contact Information: | BAA Coordinator AIM@darpa.mil Email: AIM@darpa.mil |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 12.910 | PKG00268655 | Sep 07, 2021 | Oct 26, 2021 | View |
Package 1
Mandatory forms
335379 RR_SF424_3_0-3.0.pdf
335379 AttachmentForm_1_2-1.2.pdf
335379 RR_Budget10_1_4-1.4.pdf
335379 RR_KeyPersonExpanded_3_0-3.0.pdf
335379 RR_PersonalData_1_2-1.2.pdf
Optional forms
335379 SFLLL_2_0-2.0.pdf
335379 RR_SubawardBudget10_30_1_4-1.4.pdf
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