This Department of Defense (DoD) grant, the Reimagining Protein Manufacturing (RPM) program, aims to ensure timely access to critical medical countermeasures (MCMs). It focuses on establishing foundational technologies for fully distributed, on-demand manufacturing of protein-based MCMs and associated raw materials. The program will develop technologies for immediate synthesis (approx. 24 hours lead time) of bioactive protein MCMs and production enzymes, targeting a yield of over 500 doses per week. This will enable the DoD to rapidly secure both therapeutic proteins and enzymes needed for nucleic acid-based MCM synthesis, thereby reducing reliance on complex supply chains.
Opportunity ID: 335391
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | HR001121S0038 |
| Funding Opportunity Title: | Reimagining Protein Manufacturing (RPM) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement Grant Other Procurement Contract |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 12.910 — Research and Technology Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 23, 2021 |
| Last Updated Date: | Aug 23, 2021 |
| Original Closing Date for Applications: | Nov 16, 2021 See Full Announcement for details. |
| Current Closing Date for Applications: | Nov 16, 2021 See Full Announcement for details. |
| Archive Date: | Dec 16, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | All responsible sources capable of satisfying the Government’s needs may submit a proposal that shall be considered by DARPA. See the Eligibility Information section of the BAA for more information. |
Additional Information
| Agency Name: | DARPA – Biological Technologies Office |
| Description: | The Reimagining Protein Manufacturing (RPM) program aims to ensure timely DoD access to critical medical countermeasures (MCMs) by establishing the foundational technologies needed for fully distributed, on-demand manufacturing of protein-based MCMs and associated raw materials. To achieve this goal, RPM will develop technologies to enable immediate synthesis (lead time approximately 24 hours) of bioactive protein MCMs and raw material production enzymes at a yield corresponding to > 500 doses per week. This technology will allow the DoD to rapidly secure access to both therapeutic proteins and enzymes needed for nucleic acid-based MCM synthesis, and reduce reliance on complex supply chains. |
| Link to Additional Information: | SAM.gov Contract Opportunities |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
BAA Coordinator
RPM@darpa.mil Email:RPM@darpa.mil |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 335391 Full Announcement-HR001121S0038 -> HR001121S0038.pdf
Folder 335391 Full Announcement-HR001121S0038 -> Attachment_3_HR001121S0038-Cost_Proposal_Spreadsheet.pdf
Folder 335391 Full Announcement-HR001121S0038 -> Attachment_2_HR001121S0038-SOW_Template.pdf
Folder 335391 Full Announcement-HR001121S0038 -> Attachment_1_HR001121S0038-Executive_Summary_Slide_Template.pdf
Packages
| Agency Contact Information: | BAA Coordinator RPM@darpa.mil Email: RPM@darpa.mil |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 12.910 | PKG00268663 | Aug 23, 2021 | Nov 16, 2021 | View |
Package 1
Mandatory forms
335391 RR_SF424_3_0-3.0.pdf
335391 AttachmentForm_1_2-1.2.pdf
335391 RR_Budget10_1_4-1.4.pdf
335391 RR_KeyPersonExpanded_3_0-3.0.pdf
335391 RR_PersonalData_1_2-1.2.pdf
Optional forms
335391 SFLLL_2_0-2.0.pdf
335391 RR_SubawardBudget10_30_1_4-1.4.pdf
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