The National Institutes of Health (NIH) is offering this grant to continue essential support for specific pathogen-free (SPF) macaque colonies vital for ongoing Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS) research. This grant is for the purpose of sustaining breeding colonies of SPF macaques, which are crucial for reliable research outcomes by eliminating confounding viral infections. These colonies also mitigate risks to research personnel. Furthermore, the macaques are genetically characterized for Major Histocompatibility Complex (MHC) class I types, due to their significant impact on macaque immune responses to Simian Immunodeficiency Virus (SIV), a model for human HIV. This continued support ensures the availability of high-quality animal models necessary for advancing HIV/AIDS investigations.
Opportunity ID: 351920
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-24-129 |
| Funding Opportunity Title: | Limited Competition: Specific Pathogen Free Macaque Colonies to Support HIV/AIDS Research (U42 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.310 — Trans-NIH Research Support |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jan 22, 2024 |
| Last Updated Date: | Jan 22, 2024 |
| Original Closing Date for Applications: | Jan 07, 2027 |
| Current Closing Date for Applications: | Jan 07, 2027 |
| Archive Date: | Feb 12, 2027 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. see NOFO for eligibility details |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Notice of Funding Opportunity (NOFO) is to provide continuing support for specific pathogen-free (SPF) macaque colonies previously funded under the auspices of PAR-21-089 and PAR-18-669 that support Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS) research. Breeding colonies are essential to sustain appropriate SPF macaques for research related to HIV/AIDS. Pedigree SPF macaques are free of certain viruses, which may confound the results of HIV/AIDS-related investigations or present a risk to the personnel who care for the animals. The SPF macaques are genetically characterized for major histocompatibility complex (MHC) class I types, because MHC class I genotypes have large effects on macaque immune responses to Simian Immunodeficiency Virus (SIV) that can induce AIDS in nonhuman primates (NHPs) and on human immune responses to HIV. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-24-129.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or before January 24, 2025 | PKG00284512 | Apr 07, 2024 | Jan 24, 2025 | View | |
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289338 | Dec 02, 2024 | Jan 07, 2027 | View |
Package 1
Mandatory forms
351920 RR_SF424_5_0-5.0.pdf
351920 PHS398_CoverPageSupplement_5_0-5.0.pdf
351920 RR_OtherProjectInfo_1_4-1.4.pdf
351920 PerformanceSite_4_0-4.0.pdf
351920 RR_KeyPersonExpanded_4_0-4.0.pdf
351920 PHS398_ResearchPlan_5_0-5.0.pdf
351920 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
351920 PHS_Additional_IndirectCosts_2_0-2.0.pdf
351920 PHS_AssignmentRequestForm_4_0-4.0.pdf
Package 2
Mandatory forms
351920 RR_SF424_5_0-5.0.pdf
351920 PHS398_CoverPageSupplement_5_0-5.0.pdf
351920 RR_OtherProjectInfo_1_4-1.4.pdf
351920 PerformanceSite_4_0-4.0.pdf
351920 RR_KeyPersonExpanded_4_0-4.0.pdf
351920 PHS398_ResearchPlan_5_0-5.0.pdf
351920 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
351920 PHS_Additional_IndirectCosts_2_0-2.0.pdf
351920 PHS_AssignmentRequestForm_3_0-3.0.pdf
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