This NIH grant opportunity is dedicated to advancing the discovery of pharmacotherapeutics for Substance Use Disorders (SUD) by leveraging artificial intelligence and novel experimental assays. The primary purpose is to identify new compounds with improved efficacy and reduced toxicity. This initiative focuses on two key areas. Firstly, it supports the development of sophisticated AI tools for identifying target combinations, designing new molecules, conducting virtual preclinical studies to predict efficacy and toxicity, and modeling polypharmacology. Secondly, the grant aims to foster the creation of innovative assays designed to comprehensively assess compound effects across multiple biological targets or functions. This funding is crucial for accelerating the development of safer and more effective treatments for SUD.
Opportunity ID: 352049
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DA-25-054 |
| Funding Opportunity Title: | Harnessing Artificial Intelligence and Polypharmacology to Discover Pharmacotherapeutics for Substance Use Disorders (R43/R44 Clinical Trials Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.279 — Drug Abuse and Addiction Research Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jan 29, 2024 |
| Last Updated Date: | Jan 29, 2024 |
| Original Closing Date for Applications: | Jul 25, 2024 |
| Current Closing Date for Applications: | Jul 25, 2024 |
| Archive Date: | Aug 30, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, may be allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this funding opportunity is to develop artificial intelligence tools and experimental assays to identify new pharmacotherapeutics with lower toxicity and higher efficacy for substance use disorders (SUD) Areas of interest include but are not limited to: 1) Development of AI tools to identify potential target combinations, design new molecules, conduct virtual preclinical studies to predict efficacy and toxicity, and model in vitro and in vivo polypharmacology 2) Development of assays to assess the effects of compounds on multiple targets or functions |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-25-054.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 352049 Full Announcement-RFA-DA-25-054 -> RFA-DA-25-054-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00284615 | Jun 25, 2024 | Jul 25, 2024 | View |
Package 1
Mandatory forms
352049 RR_SF424_5_0-5.0.pdf
352049 PHS398_CoverPageSupplement_5_0-5.0.pdf
352049 RR_OtherProjectInfo_1_4-1.4.pdf
352049 PerformanceSite_4_0-4.0.pdf
352049 RR_KeyPersonExpanded_4_0-4.0.pdf
352049 RR_Budget_3_0-3.0.pdf
352049 PHS398_ResearchPlan_5_0-5.0.pdf
352049 SBIR_STTR_Information_3_0-3.0.pdf
352049 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
352049 RR_SubawardBudget30_3_0-3.0.pdf
352049 PHS_AssignmentRequestForm_3_0-3.0.pdf
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