This grant addresses the critical need for mechanistic research on how environmental toxicants contribute to Alzheimer’s Disease and Related Dementias (AD/ADRD). Despite known associations, establishing causality and the biological plausibility of toxicant impacts on disease initiation or progression is challenging. This work is vital for understanding and mitigating racial and socioeconomic inequities. The grant encourages neuroscientists to explore neurotoxicant actions on the nervous system through in silico modeling, in vitro assays correlating chemical exposure to AD/ADRD biology, and in vivo studies on neurotoxicant modification of AD/ADRD targets. A key goal includes developing and validating animal models simulating human toxicant exposures, with lifespan comparisons, to advance our understanding of modifiable risk factors for AD/ADRD.
Opportunity ID: 336080
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-22-048 |
| Funding Opportunity Title: | Clinical Relevance of the Linkage between Environmental Toxicant Exposures and Alzheimers Disease and Related Dementias (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 13, 2021 |
| Last Updated Date: | Oct 13, 2021 |
| Original Closing Date for Applications: | Mar 11, 2022 |
| Current Closing Date for Applications: | Mar 11, 2022 |
| Archive Date: | Apr 16, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education For profit organizations other than small businesses City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Independent school districts State governments Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Private institutions of higher education County governments Public housing authorities/Indian housing authorities Special district governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | There is consensus that environmental toxicants are a risk factor for AD/ADRD, but causality has been largely elusive. While human studies demonstrating an association of AD/ADRD with toxicant exposures are relatively abundant, there is a clear unmet need for more mechanistic research to support or refute the clinical relevance and the biological plausibility of an impact on disease initiation, progression, or modification. This is especially important for understanding the potentially modifiable causes of racial and socioeconomic inequities. The RFA will encourage neuroscientists to conduct mechanistic AD/ADRD research on the actions of neurotoxicants on the nervous system. The scope of research includes but is not limited to in silico modeling, in vitro assay development to correlate chemical exposure to AD/ADRD biology, and in vivo studies on the modification of known AD/ADRD targets by neurotoxicants of concern, and conversely, whether known targets for these neurotoxins play a role in the etiology of AD/ADRD. The development and validation of neuropathological, neurophysiological, and neurobehavioral animal models that simulate potential toxicant exposures in humans would be one goal, and when possible, these studies will include comparisons of exposures across the lifespan. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-22-048.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 336080 Full Announcement-PAR-22-048 -> PAR-22-048-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00269302 | Feb 11, 2022 | Jan 24, 2022 | View | |
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00269818 | Feb 11, 2022 | Mar 11, 2022 | View |
Package 1
Mandatory forms
336080 RR_SF424_2_0-2.0.pdf
336080 PHS398_CoverPageSupplement_5_0-5.0.pdf
336080 RR_OtherProjectInfo_1_4-1.4.pdf
336080 PerformanceSite_2_0-2.0.pdf
336080 RR_KeyPersonExpanded_2_0-2.0.pdf
336080 PHS398_ResearchPlan_4_0-4.0.pdf
336080 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
336080 RR_Budget_1_4-1.4.pdf
336080 RR_SubawardBudget30_1_4-1.4.pdf
336080 PHS398_ModularBudget_1_2-1.2.pdf
336080 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
336080 RR_SF424_5_0-5.0.pdf
336080 PHS398_CoverPageSupplement_5_0-5.0.pdf
336080 RR_OtherProjectInfo_1_4-1.4.pdf
336080 PerformanceSite_4_0-4.0.pdf
336080 RR_KeyPersonExpanded_4_0-4.0.pdf
336080 PHS398_ResearchPlan_4_0-4.0.pdf
336080 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
336080 RR_Budget_3_0-3.0.pdf
336080 RR_SubawardBudget30_3_0-3.0.pdf
336080 PHS398_ModularBudget_1_2-1.2.pdf
336080 PHS_AssignmentRequestForm_3_0-3.0.pdf
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