This grant, offered by NIEHS, NIAAA, and NIDA, is for pilot testing and rigorous evaluation of novel candidate biomarkers and technologies measuring biological responses to chemical toxicants and environmental stressors. The purpose is to establish the potential and feasibility of applying these novel approaches to large-scale epidemiology and gene-environment studies through collaborations with existing human population studies. Applicants must describe characteristics demonstrating suitability for further testing. The two-year program aims to assess the performance, including sensitivity, specificity, reliability, and reproducibility, of these novel approaches in independent cohorts. This solicitation exclusively emphasizes the validation of promising biomarkers and technologies; projects focused on discovering or developing new ones are not appropriate.
Opportunity ID: 56617
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-ES-10-008 |
| Funding Opportunity Title: | Validation and Field Testing of Novel Biomarkers of Response to Environmental Stressors (R01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Environment Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.113 — Environmental Health |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 13, 2010 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Oct 21, 2010 |
| Current Closing Date for Applications: | Oct 21, 2010 |
| Archive Date: | Nov 21, 2010 |
| Estimated Total Program Funding: | $2,555,000 |
| Award Ceiling: | $300,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses Native American tribal organizations (other than Federally recognized tribal governments) State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Native American tribal governments (Federally recognized) Others (see text field entitled “Additional Information on Eligibility” for clarification) County governments Private institutions of higher education Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts City or township governments Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Purpose. This FOA solicits grant applications from institutions/organizations to conduct pilot testing of novel candidate biomarkers and technologies that measure biological responses to chemical toxicants and other environmental stressors. Through collaborations with existing human population studies, investigators will conduct a rigorous evaluation of the performance of novel biomarkers and technologies under a range of exposure levels and collection and storage conditions, to establish the potential and feasibility of applying these novel approaches to large-scale epidemiology and gene-environment studies. Applicants will be expected to describe characteristics of their candidate biomarkers or technologies (e.g., laboratory validation studies, limits of detection, and preliminary data from discovery cohort studies) that demonstrate their suitability for further pilot testing. The goal of this 2-year program is to assess the performance (including testing for sensitivity, specificity, reliability and reproducibility) of these novel approaches in independent cohorts. The emphasis of this FOA is the validation of promising biomarkers and technologies; projects to discover and develop new technology and biomarkers of response are not appropriate to this solicitation and will be returned as nonresponsive. Mechanism of Support. This FOA will utilize the R01 award mechanism and runs in parallel with an FOA of similar scientific scope, RFA-ES-10-007, that encourages applications to pilot test and validate new tools for measuring exposure to chemical and lifestyle stressors. Funds Available and Anticipated Number of Awards. NIEHS, NIAAA, and NIDA intend to commit a combined total of $2,555,000 to fund 5 to 6 awards through this FOA. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-ES-10-008.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| ADOBE-FORMS-B | Use for submissions intended for due dates of January 25, 2010 and beyond | PKG00020391 | Sep 21, 2010 | Oct 21, 2010 | View |
Package 1
Mandatory forms
56617 RR_SF424_1_2-1.2.pdf
56617 PerformanceSite_1_3-1.3.pdf
56617 RR_OtherProjectInfo_1_2-1.2.pdf
56617 RR_KeyPersonExpanded_1_2-1.2.pdf
56617 PHS398_CoverPageSupplement_1_4-1.4.pdf
56617 PHS398_ResearchPlan_1_3-1.3.pdf
56617 PHS398_Checklist_1_3-1.3.pdf
Optional forms
56617 PHS_CoverLetter_1_2-1.2.pdf
56617 PHS398_ModularBudget-1.1.pdf
56617 RR_Budget-1.1.pdf
56617 RR_SubawardBudget-1.2.pdf
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