This Cellular Senescence Network grant aims to establish state-of-the-art Murine Tissue Mapping Centers (TMCs). The purpose of this funding is to create a comprehensive atlas of cellular senescence in mice, complementing an existing human effort within the SenNet consortium. This murine atlas will inform ongoing human research and serve as a blueprint for future translational studies. Awarded TMCs will collaboratively generate high-resolution, multimodal, and multidimensional maps of senescent cells across various healthy murine tissues and lifespans. The initiative also seeks to develop innovative tools and technologies for identifying and characterizing senescent cells. Data will be aggregated into a searchable atlas, integrating all pipeline stages from tissue collection to advanced omics and imaging analyses at single-cell resolution.
Opportunity ID: 336325
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-RM-22-003 |
| Funding Opportunity Title: | Cellular Senescence Network: Murine Tissue Mapping Centers (U54 – Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.310 — Trans-NIH Research Support |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 27, 2021 |
| Last Updated Date: | Oct 27, 2021 |
| Original Closing Date for Applications: | Jan 19, 2022 |
| Current Closing Date for Applications: | Jan 19, 2022 |
| Archive Date: | Feb 24, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education Small businesses For profit organizations other than small businesses Public housing authorities/Indian housing authorities City or township governments County governments Special district governments Private institutions of higher education State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Funding Opportunity Announcement (FOA) is to establish state-of-the-art Tissue Mapping Centers (TMCs) within the Cellular Senescence Network (SenNet) to build an atlas of cellular senescence in mice. The overarching goal of the SenNet consortium is to identify and functionally characterize, at single-cell resolution, the heterogeneity of senescent cells across multiple human tissues in health and lifespan. A previous FOA (RFA-RM-21-008) established the TMCs to generate data and build maps in humans. The purpose of this FOA is to solicit applications that complement the human effort by generating an atlas of cell senescence in mice that will help inform the ongoing effort in humans and serve as a blueprint for future translational research performed in mice. Through collaborative efforts, the murine component of the consortium will generate a multimodal, multidimensional atlas of senescent cells in various murine tissues (tissue choices will be predominantly dictated by the corresponding human tissues already in use within the SenNet consortium); develop innovative tools and technologies to identify and characterize senescent cells; and aggregate data across the Network into a searchable atlas of murine Cellular Senescence. The TMCs solicited through this RFA will create high-resolution, high-content, multiscale biomarkers and maps of cellular senescence across the murine lifespan, to generate a murine-specific companion to the human Senescence atlas. The mouse component of the SenNet consortium will initially focus on healthy murine tissues (modified disease models are not allowed) derived from both inbred and outbred mouse strains that are commonly used and have demonstrated value in pre-clinical research. TMCs will be expected to integrate and optimize all parts of the data generation pipeline, from tissue collection and preservation through analyses at organ-, tissue- and single-cell- level using omics, imaging and other approaches, |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-22-003.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00269637 | Dec 20, 2021 | Jan 24, 2022 | View | |
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00270624 | Dec 20, 2021 | Jan 19, 2022 | View |
Package 1
Mandatory forms
336325 RR_SF424_2_0-2.0.pdf
336325 PHS398_CoverPageSupplement_5_0-5.0.pdf
336325 RR_OtherProjectInfo_1_4-1.4.pdf
336325 PerformanceSite_2_0-2.0.pdf
336325 RR_KeyPersonExpanded_2_0-2.0.pdf
336325 PHS398_ResearchPlan_4_0-4.0.pdf
336325 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
336325 PHS_Additional_IndirectCosts-1.0.pdf
336325 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
336325 RR_SF424_5_0-5.0.pdf
336325 PHS398_CoverPageSupplement_5_0-5.0.pdf
336325 RR_OtherProjectInfo_1_4-1.4.pdf
336325 PerformanceSite_4_0-4.0.pdf
336325 RR_KeyPersonExpanded_4_0-4.0.pdf
336325 PHS398_ResearchPlan_4_0-4.0.pdf
336325 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
336325 PHS_Additional_IndirectCosts_2_0-2.0.pdf
336325 PHS_AssignmentRequestForm_3_0-3.0.pdf
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