National Institute of Arthritis and Musculoskeletal and Skin Diseases Grant: Limited Competition for Multicenter Osteoarthritis Study (MOST) (U01)

The National Institute of Arthritis and Musculoskeletal and Skin Diseases is offering a limited competition grant for the Multicenter Osteoarthritis Study (MOST) investigators to renew their study for another 5-year funding period. The study focuses on individuals with knee osteoarthritis or at high risk of developing the disease, examining biomechanical factors, structural abnormalities, and biomarkers in OA. With over 7 years of data and a specimen bank for future research, this grant supports advancing knowledge in the field of knee OA. Closing date for applications is September 7, 2017.

Opportunity ID: 239469

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General Information

Document Type::	Grants Notice
Funding Opportunity Number::	PAR-13-320
Funding Opportunity Title::	Limited Competition: Multicenter Osteoarthritis Study (MOST) (U01)
Opportunity Category::	Discretionary
Opportunity Category Explanation::
Funding Instrument Type::
Category of Funding Activity::	Health
Category Explanation::
Expected Number of Awards::
Assistance Listings Number(s)::	93.866 — Aging Research
Cost Sharing or Matching Requirement::	No
Version::	Synopsis 2
Posted Date::	Aug 06, 2013
Last Updated Date::	Sep 11, 2013
Original Closing Date for Applications::	Sep 07, 2017
Current Closing Date for Applications::	Sep 07, 2017
Archive Date::	Oct 08, 2017
Estimated Total Program Funding::
Award Ceiling::	$
Award Floor::	$

Eligibility

Eligible Applicants::

Public and State controlled institutions of higher education

Additional Information on Eligibility::

Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs) ; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Additional Information

Agency Name::	National Institutes of Health
Description::	The purpose of this limited competition FOA is to allow the Multicenter Osteoarthritis Study (MOST) investigators to submit a renewal application for another 5 year funding period, providing for resubmission and possible future revision applications. This is a uniquely valuable cohort of individuals who either had knee osteoarthritis (OA) at baseline or were at high risk of developing the disease because they had one or more disease risk factors. This is the first large scale observational study in knee OA to prospectively examine the development and progression of knee OA with respect to biomechanical factors and structural abnormalities. There is more than 7 years of repeated clinical and musculoskeletal evaluations, knee radiographs and knee MRI imaging, strength measures, physical performance measures and plasma samples in 3026 individuals who were 50-79 years at enrollment. The study also created a specimen bank for future biochemical and genetic studies of biomarkers in OA.
Link to Additional Information::
Grantor Contact Information::	If you have difficulty accessing the full announcement electronically, please contact:

Version History

Version	Modification Description	Updated Date
Synopsis 2	Modified Eligibility requirements.	Sep 11, 2013
Synopsis 1

Package Status

Below are CLOSED Opportunity Package(s) no longer available for this Funding Opportunity:

Package No: 1

Assistance Listings:	93.866
Competition ID:	FORMS-C
Competition Title:	Forms-C
Opportunity Package ID:	PKG00182662
Opening Date:	Oct 05, 2013
Closing Date:	May 07, 2016
Agency Contact Information::	eRA Commons Help Desk
Who Can Apply::	Organization Applicants
mendatory_forms	SF424 (R & R) [V2.0] PHS 398 Research Plan [V2.0] PHS 398 Cover Page Supplement [V2.0] Research and Related Senior/Key Person Profile (Expanded) [V2.0] Research And Related Other Project Information [V1.3] Project/Performance Site Location(s) [V2.0]
optional_forms	R & R Subaward Budget Attachment(s) Form 5 YR 30 ATT [V1.3] Planned Enrollment Report [V1.0] PHS 398 Cumulative Inclusion Enrollment Report [V1.0] PHS 398 Modular Budget [V1.2] Research & Related Budget [V1.3]