The National Institutes of Health (NIH) is offering this grant to support the development and rigorous validation of novel, clinically and pathophysiologically relevant human cellular models for Alzheimer’s Disease-Related Dementias (ADRD). This grant is for the purpose of creating complex models that capture multi-faceted pathologies and various cell types observed in ADRDs. Validation must encompass internal, face, construct, and predictive aspects. These models should address current gaps and contribute to therapy development or a deeper understanding of human disease mechanisms and predisposition to neurodegenerative dementias. Multidisciplinary teams are highly encouraged, as is the use of, and deposition into, existing NIH cell repository resources for broader impact.
Opportunity ID: 352495
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-NS-24-032 |
| Funding Opportunity Title: | Development and Validation of Human Cellular Models for Alzheimer’s Disease-Related Dementias (ADRD) (R01 – Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Feb 16, 2024 |
| Last Updated Date: | Feb 16, 2024 |
| Original Closing Date for Applications: | Oct 21, 2024 |
| Current Closing Date for Applications: | Oct 21, 2024 |
| Archive Date: | Nov 26, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) City or township governments Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities State governments Small businesses For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal governments (Federally recognized) Special district governments Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This NOFO would support development and validation of novel clinically- and/or pathophysiologically-relevant human cellular models of ADRD. The cellular model systems would be expected to capture the multi-faceted pathologies and multiple cell types observed in ADRDs. Validation includes internal, face, construct, and predictive (to the extent possible) validation. These models can be developed/validated with the goal of supporting therapy development or better understanding of human disease mechanisms and mechanisms that uncover predisposition to developing neurodegenerative dementias. Human cellular models need to be novel, complex, and address a gap in the currently available models. Multidisciplinary teams will be highly encouraged. Leveraging the use of and depositing new cells into existing NIH cell repository resources will also be encouraged. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-24-032.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 352495 Full Announcement-RFA-NS-24-032 -> RFA-NS-24-032-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00284930 | May 20, 2024 | Oct 21, 2024 | View |
Package 1
Mandatory forms
352495 RR_SF424_5_0-5.0.pdf
352495 PHS398_CoverPageSupplement_5_0-5.0.pdf
352495 RR_OtherProjectInfo_1_4-1.4.pdf
352495 PerformanceSite_4_0-4.0.pdf
352495 RR_KeyPersonExpanded_4_0-4.0.pdf
352495 PHS398_ResearchPlan_5_0-5.0.pdf
352495 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
352495 RR_Budget_3_0-3.0.pdf
352495 RR_SubawardBudget30_3_0-3.0.pdf
352495 PHS398_ModularBudget_1_2-1.2.pdf
352495 PHS_AssignmentRequestForm_3_0-3.0.pdf
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