The National Institutes of Health (NIH) is offering this grant to support transformative research on the basic mechanisms of polysubstance use in addiction. This grant is for researchers proposing rigorous, hypothesis-based, and exploratory mechanistic studies. Projects may investigate the underlying processes of polysubstance use across multiple levels, including behavioral, cognitive, cellular, circuit, genetic, epigenetic, pharmacological, and computational. The primary purpose is to profoundly advance our understanding of polysubstance use, leading to new insights into its complex nature and contributing to more effective strategies for addiction treatment and prevention. This initiative aims to foster innovative research that can fundamentally change how addiction involving multiple substances is approached and treated.
Opportunity ID: 352519
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DA-25-043 |
| Funding Opportunity Title: | Transformative Research on the Basic Mechanisms of Polysubstance use in Addiction (R01 – Clinical Trials Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.279 — Drug Abuse and Addiction Research Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Feb 20, 2024 |
| Last Updated Date: | Feb 20, 2024 |
| Original Closing Date for Applications: | Jul 17, 2024 |
| Current Closing Date for Applications: | Jul 17, 2024 |
| Archive Date: | Aug 22, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $350,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | For profit organizations other than small businesses County governments Native American tribal organizations (other than Federally recognized tribal governments) State governments Native American tribal governments (Federally recognized) Small businesses Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) City or township governments Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This notice of funding opportunity (NOFO) will support projects proposing mechanistic studies that will transform our understanding of polysubstance use in addiction. These hypothesis-based, exploratory projects may investigate mechanisms of polysubstance use at the behavioral, cognitive, cellular, circuit, genetic, epigenetic, pharmacological and/or computational levels. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-25-043.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 352519 Full Announcement-RFA-DA-25-043 -> RFA-DA-25-043-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00287150 | Jun 24, 2024 | Jul 17, 2024 | View |
Package 1
Mandatory forms
352519 RR_SF424_5_0-5.0.pdf
352519 PHS398_CoverPageSupplement_5_0-5.0.pdf
352519 RR_OtherProjectInfo_1_4-1.4.pdf
352519 PerformanceSite_4_0-4.0.pdf
352519 RR_KeyPersonExpanded_4_0-4.0.pdf
352519 PHS398_ResearchPlan_5_0-5.0.pdf
352519 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
352519 RR_Budget_3_0-3.0.pdf
352519 RR_SubawardBudget30_3_0-3.0.pdf
352519 PHS398_ModularBudget_1_2-1.2.pdf
352519 PHS_AssignmentRequestForm_3_0-3.0.pdf
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