This National Institutes of Health (NIH) funding opportunity invites applications for the Data Coordinating Center (DCC) for the Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN). This grant is for establishing the DCC, a critical component of SIREN, which will enable high-quality, multi-site clinical trials focused on improving outcomes for patients with neurologic, cardiac, respiratory, hematologic, and trauma emergency events. The DCC’s responsibilities include comprehensive data management, ensuring data quality, statistical analysis, overseeing Data Safety Monitoring Boards, and managing regulatory reporting. The SIREN network will also include a Clinical Coordinating Center and up to ten clinical hubs. Through SIREN, at least four large (1,000-patient) pragmatic clinical trials will be conducted in emergency department and pre-hospital settings, with specific trial projects awarded via separate announcements.
Opportunity ID: 336646
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-NS-22-013 |
| Funding Opportunity Title: | Limited Competition: Network for Emergency Care Clinical Trials: Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) – Data Coordinating Center (DCC) (U24 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.233 — National Center on Sleep Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 19, 2021 |
| Last Updated Date: | Nov 19, 2021 |
| Original Closing Date for Applications: | Jan 18, 2022 |
| Current Closing Date for Applications: | Jan 18, 2022 |
| Archive Date: | Feb 23, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $290,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. See the funding announcement for eligibility |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this funding opportunity announcement (FOA) is to invite applications for the Data Coordinating Center (DCC) for Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN). SIREN will enable conduct of high-quality, multi-site clinical trials to improve the outcomes for patients with neurologic, cardiac, respiratory, hematologic, and trauma emergency events. SIREN will consist of one Clinical Coordinating Center (CCC), one Data Coordinating Center (DCC) and up to 10 clinical centers (Hubs). The DCC will have responsibility for data management, data quality, statistical analysis, Data Safety Monitoring Board(s) (DSMB) and reporting to regulatory and oversight groups. SIREN will implement a total of at least four large (1,000 patient) simple, pragmatic clinical trials in the emergency department and pre-hospital settings. The clinical trials will be meritorious, peerreviewed projects which will be awarded under separate funding announcements. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-22-013.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00270530 | Dec 18, 2021 | Jan 24, 2022 | View | |
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00270531 | Dec 18, 2021 | Jan 18, 2022 | View |
Package 1
Mandatory forms
336646 RR_SF424_2_0-2.0.pdf
336646 PHS398_CoverPageSupplement_5_0-5.0.pdf
336646 RR_OtherProjectInfo_1_4-1.4.pdf
336646 PerformanceSite_2_0-2.0.pdf
336646 RR_KeyPersonExpanded_2_0-2.0.pdf
336646 RR_Budget_1_4-1.4.pdf
336646 PHS398_ResearchPlan_4_0-4.0.pdf
336646 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
336646 RR_SubawardBudget30_1_4-1.4.pdf
336646 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
336646 RR_SF424_5_0-5.0.pdf
336646 PHS398_CoverPageSupplement_5_0-5.0.pdf
336646 RR_OtherProjectInfo_1_4-1.4.pdf
336646 PerformanceSite_4_0-4.0.pdf
336646 RR_KeyPersonExpanded_4_0-4.0.pdf
336646 RR_Budget_3_0-3.0.pdf
336646 PHS398_ResearchPlan_4_0-4.0.pdf
336646 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
336646 RR_SubawardBudget30_3_0-3.0.pdf
336646 PHS_AssignmentRequestForm_3_0-3.0.pdf
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