Department of Health and Human Services: Grant for Renewal of Aging Intervention Testing Program

This department is offering a grant to renew and expand the Aging Interventions Testing Program (ITP). The grant aims to test potential intervention strategies to slow aging in mammals by measuring lifespan extension and health improvements at later ages. Goals include testing compounds for effects on lifespan, analyzing pharmacodynamics and pharmacokinetics, increasing histology and pathophysiology analyses, conducting health span studies, and establishing a data coordinating center. Applicants should focus on the standardized testing of interventions in multiple sites. The closing date for applications is November 01, 2013.

Opportunity ID: 239076

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General Information

Document Type::	Grants Notice
Funding Opportunity Number::	RFA-AG-14-011
Funding Opportunity Title::	Limited Competition: Renewal of the Aging Intervention Testing Program (U01)
Opportunity Category::	Discretionary
Opportunity Category Explanation::
Funding Instrument Type::
Category of Funding Activity::	Health
Category Explanation::
Expected Number of Awards::	3
Assistance Listings Number(s)::	93.866 — Aging Research
Cost Sharing or Matching Requirement::	No
Version::	Synopsis 2
Posted Date::	Aug 02, 2013
Last Updated Date::	Oct 21, 2013
Original Closing Date for Applications::	Oct 21, 2013
Current Closing Date for Applications::	Nov 01, 2013
Archive Date::	Dec 01, 2013
Estimated Total Program Funding::	$ 4,800,000
Award Ceiling::	$3,000,000
Award Floor::	$

Eligibility

Eligible Applicants::

Others (see text field entitled “Additional Information on Eligibility” for clarification)

Additional Information on Eligibility::

Other Eligible Applicants include the following:
Only the current awardees of Intervention Testing Program (ITP) funded under RFA-AG-09-013 are eligible to apply under this Limited Competition FOA.

Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Additional Information

Agency Name::	National Institutes of Health
Description::	The purpose of the Aging Interventions Testing Program (ITP) is to test, under standardized conditions in multiple sites, potential intervention strategies which may decelerate the rate of aging in mammals. The rate of aging is to be measured by lifespan extension and/or improvements in health at later ages due to the intervention. The ITP has used life span as its primary outcome for an intervention, with limited studies on end-of-life pathologies and selected tests of health across the lifespan (health span). This FOA calls for renewal and expansion of the ITP with the following goals: 1. Continue to test compounds for effects on lifespan; 2. Increase analysis of pharmacodynamics and pharmacokinetics of compounds proposed for lifespan studies, including studies of optimal effective dose; 3. Increase histology and pathophysiology analyses at time-of-death; 4. Increase focused studies of health span on selected compounds; 5. Establish a data coordinating center.
Link to Additional Information::
Grantor Contact Information::	If you have difficulty accessing the full announcement electronically, please contact:

Version History

Version	Modification Description	Updated Date
Synopsis 2	Modified Archive Date based on new Expiration Date, per NOT-OD-14-003.	Oct 21, 2013
Synopsis 1

Package Status

Below are CLOSED Opportunity Package(s) no longer available for this Funding Opportunity:

Package No: 1

Assistance Listings:	93.866
Competition ID:	FORMS-C
Competition Title:	Forms-C
Opportunity Package ID:	PKG00182333
Opening Date:	Sep 21, 2013
Closing Date:	Nov 01, 2013
Agency Contact Information::	eRA Commons Help Desk
Who Can Apply::	Organization Applicants
mendatory_forms	SF424 (R & R) [V2.0] PHS 398 Research Plan [V2.0] PHS 398 Cover Page Supplement [V2.0] Research and Related Senior/Key Person Profile (Expanded) [V2.0] Research And Related Other Project Information [V1.3] Project/Performance Site Location(s) [V2.0]
optional_forms	R & R Subaward Budget Attachment(s) Form 5 YR 30 ATT [V1.3] Planned Enrollment Report [V1.0] PHS 398 Cumulative Inclusion Enrollment Report [V1.0] PHS 398 Modular Budget [V1.2] Research & Related Budget [V1.3]