The National Institute on Drug Abuse (NIDA) is offering this R21 Exploratory/Developmental grant to support the development of biological assays for neuronal nicotinic acetylcholine receptors (nAChRs). The primary goal is to create high throughput screening (HTS) compatible assays for constitutive receptor combinations involving 3, 5, 6, and/or 4 subunits. Genetic studies have linked variants in nAChR subunits, such as 5-3-4, to nicotine addiction and tobacco dependence. These assays will facilitate the discovery of new molecular probes and biologically active compounds from large chemical libraries. Identified compounds will serve as lead molecules for selective ligand development and guide drug discovery efforts, ultimately aiding in the development of tobacco smoking cessation medications. Approximately $1.5 million is available for 5-7 awards in 2011.
Opportunity ID: 57576
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DA-11-007 |
| Funding Opportunity Title: | Assay Development for High Throughput Screening for Nicotinic Receptor Subunits (R21) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.279 — Drug Abuse and Addiction Research Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Sep 16, 2010 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Jan 18, 2011 |
| Current Closing Date for Applications: | Jan 18, 2011 |
| Archive Date: | Feb 18, 2011 |
| Estimated Total Program Funding: | $1,500,000 |
| Award Ceiling: | $150,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Independent school districts Native American tribal governments (Federally recognized) City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Public housing authorities/Indian housing authorities Private institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) County governments Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Special district governments For profit organizations other than small businesses Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Purpose. This FOA, issued by the National Institute on Drug Abuse (NIDA), requests applications that propose to develop biological assays that will facilitate the discovery of new molecular probes for investigating the biological function of neuronal nicotinic acetylcholine receptors (nAChRs). Membrane-spanning subunits (alpha and beta) aggregate in pentamers to form various combinations of functional nAChR ion channels. Genetic association studies have implicated variants in the 5-3-4 cholinergic nicotinic receptor subunit gene cluster on chromosome 15q24-25.1 for the risk of nicotine addiction, tobacco dependence, smoking, and lung cancer. Other studies have implicated the 6-subunit in nicotine addiction. This FOA seeks applications proposing to develop biological assays for constitutive receptor combinations involving 3, 5, 6, and/or 4 subunits, suitable ultimately for configuration as high throughput screening (HTS) assays. Once developed, these HTS-ready assays can, and will be expected to be, submitted for screening (http://grants.nih.gov/grants/guide/notice-files/NOT-RM-09-011.html ) by the National Institutes of Health (NIH) Molecular Libraries Production Centers Network (MLPCN) to identify biologically active compounds in a large library of small molecule chemical structures. The chemical structures uncovered through development and use of these assays could then be used for selective ligand development and as possible lead molecules to guide drug discovery in the development of tobacco smoking cessation medications. Mechanism of Support. This FOA will use the NIH Exploratory/Developmental (R21) grant mechanism with modifications. Funds Available and Anticipated Number of Awards. Approximately $1.5 million will be available for this FOA in 2011. NIDA anticipates making approximately 5-7 awards in 2011. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-11-007.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 93.279 | ADOBE-FORMS-B1 | ADOBE-FORMS-B1 | PKG00021272 | Dec 18, 2010 | Jan 18, 2011 | View |
Package 1
Mandatory forms
57576 RR_SF424_1_2-1.2.pdf
57576 RR_OtherProjectInfo_1_3-1.3.pdf
57576 RR_KeyPersonExpanded_1_2-1.2.pdf
57576 PerformanceSite_1_4-1.4.pdf
57576 PHS398_ResearchPlan_1_3-1.3.pdf
57576 PHS398_CoverPageSupplement_1_4-1.4.pdf
57576 PHS398_Checklist_1_3-1.3.pdf
Optional forms
57576 RR_Budget-1.1.pdf
57576 RR_SubawardBudget-1.2.pdf
57576 PHS_CoverLetter_1_2-1.2.pdf
57576 PHS398_ModularBudget-1.1.pdf
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