The National Institute on Aging (NIA) invites applications for a clinical trial investigating the effects of vitamin D supplementation on functional outcomes in older adults. This six-year grant supports a randomized controlled trial to determine the dose-response and efficacy of vitamin D in preventing falls, with gait speed proposed as a secondary outcome. Applicants should aim for sufficient power across various doses and baseline vitamin D levels. Advanced, cost-efficient designs like adaptive trials are encouraged. The initial nine months of the award will fund crucial pilot studies to test recruitment strategies, assess participant eligibility and willingness, and finalize the study protocol, data collection forms, and manual of procedures for the trial.
Opportunity ID: 237318
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AG-14-001 |
| Funding Opportunity Title: | Dose Response and Efficacy Studies on the Effects of Vitamin D Supplementation on Functional Outcomes in Elderly (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.866 — Aging Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jul 08, 2013 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Sep 23, 2013 |
| Current Closing Date for Applications: | Sep 23, 2013 |
| Archive Date: | Oct 24, 2013 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | For profit organizations other than small businesses Special district governments City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) County governments Private institutions of higher education Native American tribal governments (Federally recognized) Small businesses State governments Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The National Institute on Aging (NIA) invites applications for a clinical trial on effects of vitamin D supplementation on falls and gait speed in older individuals. During the six-year support period, the awardee will implement a randomized controlled trial with sufficient power to determine the doseresponse and efficacy of vitamin D supplementation in preventing falls, across a range of doses and baseline vitamin D levels. A measurement of effects of supplementation on gait speed should be proposed as a secondary outcome. Applicants are strongly encouraged to consider advanced, cost-efficient designs that include a dose-ranging phase followed by an efficacy phase for select doses (e.g., adaptive designs). The first nine months of the award will provide funds to conduct pilot studies to test recruitment strategies, determine the proportion of those screened who are both eligible and willing to be randomized, and finalize the study protocol, data collection forms and manual of procedures for the trial. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-14-001.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 93.866 | FORMS-C | Use for due dates after 9/24/2013 | PKG00180443 | Aug 23, 2013 | Sep 23, 2013 | View |
| 93.866 | ADOBE-FORMS-B2 | Adobe-Forms-B2 | PKG00183592 | Aug 23, 2013 | Sep 23, 2013 | View |
Package 1
Mandatory forms
237318 RR_SF424_2_0-2.0.pdf
237318 PHS398_ResearchPlan_2_0-2.0.pdf
237318 PHS398_CoverPageSupplement_2_0-2.0.pdf
237318 RR_KeyPersonExpanded_2_0-2.0.pdf
237318 RR_OtherProjectInfo_1_3-1.3.pdf
237318 PerformanceSite_2_0-2.0.pdf
Optional forms
237318 RR_SubawardBudget30_1_3-1.3.pdf
237318 PlannedReport-1.0.pdf
237318 PHS398_CumulativeInclusionReport-1.0.pdf
237318 PHS398_ModularBudget_1_2-1.2.pdf
237318 RR_Budget_1_3-1.3.pdf
Package 2
Mandatory forms
237318 RR_SF424_1_2-1.2.pdf
237318 PerformanceSite_1_4-1.4.pdf
237318 RR_OtherProjectInfo_1_3-1.3.pdf
237318 RR_KeyPersonExpanded_1_2-1.2.pdf
237318 PHS398_CoverPageSupplement_1_4-1.4.pdf
237318 PHS398_ResearchPlan_1_3-1.3.pdf
237318 PHS398_Checklist_1_3-1.3.pdf
Optional forms
237318 RR_SubawardBudget30-1.2.pdf
237318 PHS398_ModularBudget_1_2-1.2.pdf
237318 RR_Budget-1.1.pdf
237318 PHS_CoverLetter_1_2-1.2.pdf
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