This grant is for supporting research aimed at understanding the critical role of lipids in brain aging, Alzheimer’s disease (AD), and its related dementias (ADRD). The funding seeks to bridge knowledge gaps by investigating how lipids contribute to both vulnerability and resilience. Specific research areas include exploring the impact of lipid droplets on brain aging and AD, examining interactions between peripheral and brain lipids as potential biomarkers, analyzing the influence of APOE and lipid-mediated signaling on AD/ADRD progression, and understanding the contribution of myelin lipids and their signaling to brain aging and dementia. The goal is to advance our comprehension of lipid mechanisms in neurodegeneration.
Opportunity ID: 337166
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AG-23-009 |
| Funding Opportunity Title: | Lipids in Brain Aging and Alzheimer’s Disease (AD) and its Related Dementias (ADRD) (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.866 — Aging Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 28, 2021 |
| Last Updated Date: | Dec 28, 2021 |
| Original Closing Date for Applications: | Jun 14, 2022 |
| Current Closing Date for Applications: | Jun 14, 2022 |
| Archive Date: | Jul 20, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Small businesses Special district governments For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Public housing authorities/Indian housing authorities State governments Native American tribal governments (Federally recognized) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The goal of this Funding Opportunity Announcement (FOA)is to support research addressing critical knowledge gaps in our understanding of how lipids contribute to vulnerability and resilience to brain aging and Alzheimers disease (AD)and its related dementias (ADRD), including research addressing how: 1) lipid droplets affect brain aging and AD, including whether their accumulation is pathological or protective; (2) the periphery interacts with lipids in the aging brain, including whether these could be targets for future biomarkers; (3) APOE and lipid-mediated signaling influence brain aging and AD/ADRD progression; and (4) myelin lipids and their signaling contribute to brain aging and AD/ADRD. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-23-009.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 337166 Full Announcement-RFA-AG-23-009 -> RFA-AG-23-009-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00271123 | May 15, 2022 | Jun 14, 2022 | View |
Package 1
Mandatory forms
337166 RR_SF424_5_0-5.0.pdf
337166 PHS398_CoverPageSupplement_5_0-5.0.pdf
337166 RR_OtherProjectInfo_1_4-1.4.pdf
337166 PerformanceSite_4_0-4.0.pdf
337166 RR_KeyPersonExpanded_4_0-4.0.pdf
337166 PHS398_ResearchPlan_4_0-4.0.pdf
337166 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
337166 RR_Budget_3_0-3.0.pdf
337166 RR_SubawardBudget30_3_0-3.0.pdf
337166 PHS398_ModularBudget_1_2-1.2.pdf
337166 PHS_AssignmentRequestForm_3_0-3.0.pdf
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