This grant aims to support research into the physiological mechanisms underlying cognitive fluctuations (CF) in Alzheimer’s and Related Dementias (ADRD) populations. CF, a core feature of some dementias like Lewy Body Dementia, are unpredictable, vary in duration, and significantly impact patient functioning. While prior studies suggest links to epileptiform discharges and altered brain activity, the full etiology is complex, potentially involving dysautonomia, orthostasis, and sleep disturbances, and may differ across dementia types. Understanding these diverse mechanisms is crucial for developing effective treatments and improving patient quality of life. This initiative encourages projects that characterize CF physiology, ideally incorporating wearable digital devices for timely data capture. Proposals may investigate multiple mechanisms within a specific ADRD population or compare mechanisms across different ADRD types.
Opportunity ID: 353033
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-NS-25-014 |
| Funding Opportunity Title: | Mechanisms of Cognitive Fluctuations in ADRD Populations (R01 – Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Mar 18, 2024 |
| Last Updated Date: | Mar 18, 2024 |
| Original Closing Date for Applications: | Jun 24, 2024 |
| Current Closing Date for Applications: | Jun 24, 2024 |
| Archive Date: | Jul 30, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $825,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Small businesses County governments Public housing authorities/Indian housing authorities State governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal governments (Federally recognized) City or township governments For profit organizations other than small businesses Private institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | “Fluctuating cognition can occur in many types of dementia and is a core clinical feature of Dementia with Lewy Bodies. Cognitive fluctuations can last from seconds to days, are unpredictable (e.g., do not just occur in the evenings, as with sun-downing), and are associated with poor daily functioning for the patient. A number of small studies have suggested that cognitive fluctuations in subjects with dementia may be related to epileptiform discharges and impaired oscillatory activity on EEG, but it is not clear that these are the only factors involved in patient populations that often experience dysautonomia, orthostasis, and sleep disturbances. The etiology of cognitive fluctuations may be multi-factorial and may vary in different dementia populations. Understanding the physiology related to cognitive fluctuations is a critical next step to the development of treatment approaches and improving quality of life for these patients. This initiate would encourage research that will better characterize the physiology responsible for cognitive fluctuations in ADRD populations. Given their variable appearance and time course, it is anticipated that wearable digital devices will be important for capturing fluctuations in a timely fashion, and applicants should consider incorporating those device(s) capable of acquiring the relevant data to support the hypothesized mechanism(s). Applicants may focus on assessing multiple mechanisms in a specific ADRD population, or may chose to compare mechanisms across multiple types of ADRDs. “ |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-25-014.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 353033 Full Announcement-RFA-NS-25-014 -> RFA-NS-25-014-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00285425 | May 24, 2024 | Jun 24, 2024 | View |
Package 1
Mandatory forms
353033 RR_SF424_5_0-5.0.pdf
353033 PHS398_CoverPageSupplement_5_0-5.0.pdf
353033 RR_OtherProjectInfo_1_4-1.4.pdf
353033 PerformanceSite_4_0-4.0.pdf
353033 RR_KeyPersonExpanded_4_0-4.0.pdf
353033 PHS398_ResearchPlan_5_0-5.0.pdf
353033 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
353033 RR_Budget_3_0-3.0.pdf
353033 RR_SubawardBudget30_3_0-3.0.pdf
353033 PHS398_ModularBudget_1_2-1.2.pdf
353033 PHS_AssignmentRequestForm_3_0-3.0.pdf
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