This grant is for establishing testing laboratories as part of the NINDS Stroke Preclinical Assessment Network (SPAN). Its primary purpose is to facilitate the rigorous preclinical testing of promising cerebroprotective drugs and interventions. These interventions will be evaluated in experimental ischemic stroke models, administered either before or during reperfusion. Successful applicant laboratories will form the core infrastructure of the SPAN network, collaborating with a Coordinating Center and various intervention contributors. This collaborative effort aims to conduct parallel testing of multiple cerebroprotective therapies efficiently. Ultimately, the grant seeks to accelerate the identification of the most effective neuroprotective treatments, bridging the critical gap between preclinical research and pivotal clinical trials in a cost- and time-effective manner, thereby advancing stroke care.
Opportunity ID: 337235
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-NS-22-003 |
| Funding Opportunity Title: | Stroke Preclinical Assessment Network (SPAN) to Support Translational Studies for Acute Cerebroprotection – Testing Laboratories (U01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jan 06, 2022 |
| Last Updated Date: | Jan 06, 2022 |
| Original Closing Date for Applications: | Mar 14, 2022 |
| Current Closing Date for Applications: | Mar 14, 2022 |
| Archive Date: | Apr 19, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $400,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities For profit organizations other than small businesses County governments Native American tribal governments (Federally recognized) Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Private institutions of higher education State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Independent school districts |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this funding opportunity announcement (FOA) is to invite applications for testing laboratories to take part in the NINDS Stroke Preclinical Assessment Network (SPAN). SPAN will facilitate the testing of up to 8 promising cerebroprotective drugs or interventions to be given prior to or at the time of reperfusion in experimental models of ischemic stroke (e.g., transient middle cerebral artery occlusion (tMCAO)). Awarded testing laboratories will compose the main infrastructure of the network and will be expected to work with the SPAN Coordinating Center and intervention contributors to facilitate the parallel testing of multiple cerebroprotective interventions in experimental models of ischemic stroke. If successful, this network will accelerate the identification of the most promising neuroprotective therapies for future pivotal clinical trials and span the gap between preclinical and clinical testing, in a cost-and time-effective fashion |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-22-003.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 337235 Full Announcement-RFA-NS-22-003 -> RFA-NS-22-003-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00271233 | Feb 14, 2022 | Mar 14, 2022 | View |
Package 1
Mandatory forms
337235 RR_SF424_5_0-5.0.pdf
337235 PHS398_CoverPageSupplement_5_0-5.0.pdf
337235 RR_OtherProjectInfo_1_4-1.4.pdf
337235 PerformanceSite_4_0-4.0.pdf
337235 RR_KeyPersonExpanded_4_0-4.0.pdf
337235 PHS398_ResearchPlan_4_0-4.0.pdf
337235 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
337235 RR_Budget_3_0-3.0.pdf
337235 RR_SubawardBudget30_3_0-3.0.pdf
337235 PHS398_ModularBudget_1_2-1.2.pdf
337235 PHS_AssignmentRequestForm_3_0-3.0.pdf
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