This NINDS grant is for the Stroke Preclinical Assessment Network (SPAN) Coordinating Center. Recent advancements in endovascular thrombectomy highlight a need for adjunctive neuroprotective therapies to improve outcomes in acute stroke. This funding opportunity invites applications for a Coordinating Center to oversee the NIH SPAN initiative. SPAN will rigorously test up to six promising neuroprotective drugs or interventions in experimental ischemic stroke models, administered pre- or post-reperfusion. The selected Coordinating Center will provide essential centralized administrative oversight and coordination for all network activities, collaborating with awarded research sites. The network aims to accelerate the identification of effective neuroprotective therapies, bridging the preclinical-to-clinical testing gap efficiently, and ultimately advancing treatments for acute cerebroprotection.
Opportunity ID: 337251
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-NS-22-004 |
| Funding Opportunity Title: | Limited Competition: Stroke Preclinical Assessment Network (SPAN) to Support Translational Studies for Acute Cerebroprotection – Coordinating Center (U24 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jan 06, 2022 |
| Last Updated Date: | Jan 06, 2022 |
| Original Closing Date for Applications: | Mar 14, 2022 |
| Current Closing Date for Applications: | Mar 14, 2022 |
| Archive Date: | Apr 19, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $600,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities Others (see text field entitled “Additional Information on Eligibility” for clarification) Independent school districts |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Recent advances in endovascular thrombectomy offer a new opportunity to reconsider neuroprotective agents as adjunctive therapies to extend the time window for reperfusion and to improve long-term functional outcome. The purpose of this funding opportunity announcement (FOA) issued by NINDS is to invite applications for the Coordinating Center (CC) for the NIH Stroke Preclinical Assessment Network (SPAN). SPAN will facilitate testing of up to 6 promising neuroprotective drugs or interventions to be given prior to or at the time of reperfusion in experimental models of ischemic stroke (e.g., transient middle cerebral artery occlusion). The CC will work with the awarded network sites (RFA-NS-18-033) and will provide centralized administrative oversight and coordination of all aspects of the network. If successful, this network will accelerate the identification of the most promising neuroprotective therapies for future pivotal clinical trials and span the gap between preclinical and clinical testing, in a cost-and time-effective fashion. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-22-004.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 337251 Full Announcement-RFA-NS-22-004 -> RFA-NS-22-004-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00271234 | Feb 14, 2022 | Mar 14, 2022 | View |
Package 1
Mandatory forms
337251 RR_SF424_5_0-5.0.pdf
337251 PHS398_CoverPageSupplement_5_0-5.0.pdf
337251 RR_OtherProjectInfo_1_4-1.4.pdf
337251 PerformanceSite_4_0-4.0.pdf
337251 RR_KeyPersonExpanded_4_0-4.0.pdf
337251 RR_Budget_3_0-3.0.pdf
337251 PHS398_ResearchPlan_4_0-4.0.pdf
337251 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
337251 RR_SubawardBudget30_3_0-3.0.pdf
337251 PHS_AssignmentRequestForm_3_0-3.0.pdf
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