DARPA is soliciting research proposals for the development of synthetic regulatory genetic elements designed for use in mammalian cells. This grant aims to advance fundamental approaches for the broad application of these elements in vivo, specifically for biomedical purposes such as detecting, treating, or preventing disease. Key technical challenges include the discovery, characterization, design, and demonstration of orthogonal and modular genetic regulatory elements. Proposers must also address construct stability, function within the cell, and efficient synthesis, amplification, and delivery of novel circuits. The designed modules must maintain independent function and limit interactions with cellular metabolism to achieve their intended clinical effect. Research that offers only evolutionary improvements to current practices is excluded.
Opportunity ID: 58910
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | DARPA-BAA-11-23 |
| Funding Opportunity Title: | Controlling Cellular Machinery – Diagnostics and Therapeutics |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement Procurement Contract |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 12.910 — Research and Technology Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 29, 2010 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Mar 03, 2011 |
| Current Closing Date for Applications: | Mar 03, 2011 |
| Archive Date: | May 03, 2011 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | DARPA – Defense Sciences Office |
| Description: | DARPA is soliciting research proposals for the development of synthetic regulatory genetic elements that can be used in mammalian cells. The proposed research should comprise approaches that enable fundamental advances to the development and broad application of synthetic regulatory elements for in vivo biomedical applications to detect, treat, or prevent disease. Technical challenges that need to be addressed include, but are not limited to, discovery, characterization, evolution or design, and demonstration of orthogonal and modular genetic regulatory elements; construct stability and function in the cell; and synthesis, amplification, and delivery of novel circuits in mammalian cells. The designed modules must limit specific interactions with the cellular metabolism or milieu to the desired performance characteristics and demonstrate maintenance of independent function without interference long enough to achieve the intended clinical effect. Specifically excluded is research that primarily results in evolutionary improvements to the existing state of practice. Proposers that intend to pursue nucleic acid vaccines as an application are referred to the companion announcement, Controlling Cellular Machinery – Vaccines, DARPA-BAA-11-22. |
| Link to Additional Information: | – |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
Dr. Daniel Wattendorf
Email:DARPA-BAA-11-23@darpa.mil |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | Dr. Daniel Wattendorf Email: DARPA-BAA-11-23@darpa.mil |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 12.910 | PKG00022669 | Nov 29, 2010 | Mar 03, 2011 | View |
Package 1
Mandatory forms
58910 RR_SF424-1.1.pdf
Optional forms
58910 RR_FedNonFedBudget-1.1.pdf
58910 RR_FedNonFed_SubawardBudget-1.2.pdf
58910 RR_OtherProjectInfo-1.1.pdf
58910 RR_Budget-1.1.pdf
58910 RR_KeyPersonExpanded-1.1.pdf
58910 RR_PerformanceSite-1.1.pdf
58910 RR_SubawardBudget-1.2.pdf
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