This grant is for developing biomarkers of mitochondrial dysfunction using animal and other experimental models. The purpose is to identify environmental stressors that inhibit normal mitochondrial function, improve the mechanistic understanding of mitochondrial toxicants, and develop approaches for human population studies linking exposure to disease. Mitochondrial biology is complex, with varied responses to stressors, diet, and genetics across tissues and developmental stages. Key issues to address include understanding how severe effects in target tissues relate to milder effects in surrogates, distinguishing adaptive from adverse alterations, and identifying early endpoints before severe tissue phenotypes become apparent. Relevant models are crucial for developing robust markers.
Opportunity ID: 58919
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-ES-11-007 |
| Funding Opportunity Title: | Identification of Biomarkers for Early Detection of Environmentally-Induced Mitochondrial Dysfunction (R01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Environment Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.113 — Environmental Health |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 30, 2010 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Feb 03, 2011 |
| Current Closing Date for Applications: | Feb 03, 2011 |
| Archive Date: | Mar 06, 2011 |
| Estimated Total Program Funding: | $2,500,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments City or township governments Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments County governments Private institutions of higher education Independent school districts For profit organizations other than small businesses Public and State controlled institutions of higher education Small businesses Public housing authorities/Indian housing authorities Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This funding opportunity announcement (FOA) encourages grant applications from institutions/organizations to develop biomarkers of mitochondrial dysfunction using animal models and other experimental models that can help to identify environmental stressors that inhibit normal mitochondrial function, improve our mechanistic understanding of the effects of mitochondrial toxicants, and develop approaches and candidate markers that will serve as the basis for developing biomarkers of early mitochondrial dysfunction in human population studies linking exposure to disease. Mitochondrial biology is complex, with different responses to stressors, diet composition, and genetic factors observed in different tissues and at different stages of development. Before early biomarkers of mitochondrial dysfunction can be fully developed for human studies, a number of important issues need to be addressed, including enhancing the understanding of how the more severe effects on mitochondrial function in target tissues relate to milder effects in surrogate tissues, understanding whether alterations in mitochondrial endpoints are adaptive or adverse (transient or persistent) effects, and determining which endpoints signal early effects on mitochondrial function before more severe tissue phenotypes are apparent. Many of these questions can be addressed through development of relevant animal and other experimental models to identify robust markers of mitochondrial dysfunction associated with genetic and environmental factors. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-ES-11-007.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 93.113 | ADOBE-FORMS-B1 | ADOBE-FORMS-B1 | PKG00022683 | Jan 03, 2011 | Feb 03, 2011 | View |
Package 1
Mandatory forms
58919 RR_SF424_1_2-1.2.pdf
58919 RR_OtherProjectInfo_1_3-1.3.pdf
58919 RR_KeyPersonExpanded_1_2-1.2.pdf
58919 PerformanceSite_1_4-1.4.pdf
58919 PHS398_ResearchPlan_1_3-1.3.pdf
58919 PHS398_CoverPageSupplement_1_4-1.4.pdf
58919 PHS398_Checklist_1_3-1.3.pdf
Optional forms
58919 RR_Budget-1.1.pdf
58919 RR_SubawardBudget-1.2.pdf
58919 PHS_CoverLetter_1_2-1.2.pdf
58919 PHS398_ModularBudget-1.1.pdf
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