This grant is for advancing the understanding of psychiatric and neurodevelopmental disorders by supporting systematic, scalable approaches to profile the biological function of risk genes. Current research faces a bottleneck due to limited scalable experimental platforms for translating disease-associated genes into biological insights. This initiative aims to bridge this gap by enabling large-scale, high-throughput assays using new technologies. It will investigate how disease-linked genetic variations impact neural function across molecular, cellular, and physiological levels, studying hundreds of genes in parallel. The grant supports forming a consortium of full-scale and pilot projects for comprehensive risk gene characterization. A Consortium Coordination Center will provide administrative oversight, harmonize data and tools, develop an open-source data portal, and create standardized biological resources for the research community.
Opportunity ID: 337447
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-MH-22-110 |
| Funding Opportunity Title: | Scalable and Systematic Neurobiology of Psychiatric and Neurodevelopmental Disorder Risk Genes: Data Resource and Administrative Coordination Center (U24 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jan 19, 2022 |
| Last Updated Date: | Jan 19, 2022 |
| Original Closing Date for Applications: | Jun 10, 2022 |
| Current Closing Date for Applications: | Jun 10, 2022 |
| Archive Date: | Jul 16, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) City or township governments Independent school districts Public and State controlled institutions of higher education For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Private institutions of higher education Native American tribal governments (Federally recognized) Small businesses State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities County governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This funding opportunity announcement (FOA) supports systematic and scalable approaches to profile the biological function of genes with an excess of damaging mutations in patients with neurodevelopmental and psychiatric disorders. Current understanding of the relationship between genetic and phenotypic variation is limited and one of the main bottlenecks in translating disease-associated genes to biology lies in the lack of scalable experimental platforms that can extend the unbiased nature of gene discovery to the discovery of biological mechanisms. This concept will attempt to fill that gap while also providing a bridge between existing NIMH efforts such as PsychENCODE and Convergent Neuroscience. New technologies and approaches are now making it possible to systematically implement high-throughput assays to determine how disease-linked genetic variation impacts neural function across biological levels of organization. This initiative proposes a series of FOAs to support the large-scale implementation of high-throughput assays to interrogate the molecular, cellular and physiological function of hundreds of disease-associated genes in parallel. A combination of full-scale and pilot projects will form a consortium for broad characterization of risk genes across an array of endpoints relevant to CNS function using a variety of experimental platforms (e.g., cellular, organismal). A consortium coordination center (CCC) will serve as a central hub providing administrative coordination across projects, including data and tools harmonization, development of an open-source portal to create a unified dataset and creating a standardized set of biological resources for use by the research community. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-22-110.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 337447 Full Announcement-RFA-MH-22-110 -> RFA-MH-22-110-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00271405 | May 10, 2022 | Jun 10, 2022 | View |
Package 1
Mandatory forms
337447 RR_SF424_5_0-5.0.pdf
337447 PHS398_CoverPageSupplement_5_0-5.0.pdf
337447 RR_OtherProjectInfo_1_4-1.4.pdf
337447 PerformanceSite_4_0-4.0.pdf
337447 RR_KeyPersonExpanded_4_0-4.0.pdf
337447 RR_Budget_3_0-3.0.pdf
337447 PHS398_ResearchPlan_4_0-4.0.pdf
337447 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
337447 RR_SubawardBudget30_3_0-3.0.pdf
337447 PHS_AssignmentRequestForm_3_0-3.0.pdf
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