This NIMH grant supports systematic, scalable approaches to profile the biological function of genes linked to neurodevelopmental and psychiatric disorders. Current understanding is limited by the lack of high-throughput experimental platforms to translate genetic discoveries into mechanisms. This initiative addresses that by funding large-scale, high-throughput assays to determine how disease-linked genetic variation impacts neural function across molecular, cellular, and physiological levels. A consortium of full-scale and pilot projects will characterize risk genes. A central Consortium Coordination Center will oversee administration, harmonize data and tools, establish an open-source data portal, and standardize biological resources for the research community.
Opportunity ID: 337448
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-MH-22-111 |
| Funding Opportunity Title: | Scalable and Systematic Neurobiology of Psychiatric and Neurodevelopmental Disorder Risk Genes: Assay and Data Generation Centers (RM1 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jan 19, 2022 |
| Last Updated Date: | Jan 19, 2022 |
| Original Closing Date for Applications: | Jun 10, 2022 |
| Current Closing Date for Applications: | Jun 10, 2022 |
| Archive Date: | Jul 16, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments Public and State controlled institutions of higher education County governments Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Private institutions of higher education Small businesses State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) City or township governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This funding opportunity announcement (FOA) supports systematic and scalable approaches to profile the biological function of genes with an excess of damaging mutations in patients with neurodevelopmental and psychiatric disorders. Current understanding of the relationship between genetic and phenotypic variation is limited and one of the main bottlenecks in translating disease-associated genes to biology lies in the lack of scalable experimental platforms that can extend the unbiased nature of gene discovery to the discovery of biological mechanisms. This concept will attempt to fill that gap while also providing a bridge between existing NIMH efforts such as PsychENCODE and Convergent Neuroscience. New technologies and approaches are now making it possible to systematically implement high-throughput assays to determine how disease-linked genetic variation impacts neural function across biological levels of organization. This initiative proposes a series of FOAs to support the large-scale implementation of high-throughput assays to interrogate the molecular, cellular and physiological function of hundreds of disease-associated genes in parallel. A combination of full-scale and pilot projects will form a consortium for broad characterization of risk genes across an array of endpoints relevant to CNS function using a variety of experimental platforms (e.g., cellular, organismal). A consortium coordination center (CCC) will serve as a central hub providing administrative coordination across projects, including data and tools harmonization, development of an open-source portal to create a unified dataset and creating a standardized set of biological resources for use by the research community. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-22-111.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 337448 Full Announcement-RFA-MH-22-111 -> RFA-MH-22-111-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00271417 | May 10, 2022 | Jun 10, 2022 | View |
Package 1
Mandatory forms
337448 RR_SF424_5_0-5.0.pdf
337448 PHS398_CoverPageSupplement_5_0-5.0.pdf
337448 RR_OtherProjectInfo_1_4-1.4.pdf
337448 PerformanceSite_4_0-4.0.pdf
337448 RR_KeyPersonExpanded_4_0-4.0.pdf
337448 RR_Budget_3_0-3.0.pdf
337448 PHS398_ResearchPlan_4_0-4.0.pdf
337448 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
337448 RR_SubawardBudget30_3_0-3.0.pdf
337448 PHS_AssignmentRequestForm_3_0-3.0.pdf
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