This grant is for resolving critical immunologic and physiologic barriers that currently impede safe and effective xenotransplantation. The Immunobiology of Xenotransplantation Cooperative Research Program (IXCRP) is a multi-center initiative seeking applications to conduct preclinical research. The focus is on robust pig-to-nonhuman primate (NHP) or human decedent models, covering key organs such as pancreatic islet, kidney, heart, lung, or liver xenotransplantation. The primary purpose is to systematically address existing challenges by developing innovative strategies and understanding the underlying mechanisms necessary to ensure long-term graft survival and enhance patient safety. This unique funding opportunity aims to foster highly collaborative efforts, significantly advancing scientific understanding and innovation crucial for the future success of organ transplantation through rigorous preclinical studies.
Opportunity ID: 353310
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AI-24-020 |
| Funding Opportunity Title: | Immunobiology of Xenotransplantation (U19 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.855 — Allergy and Infectious Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Apr 01, 2024 |
| Last Updated Date: | Apr 01, 2024 |
| Original Closing Date for Applications: | Aug 09, 2024 |
| Current Closing Date for Applications: | Aug 09, 2024 |
| Archive Date: | Sep 14, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | State governments County governments Special district governments For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this notice of funding opportunity (NOFO) is to solicit applications to participate in the Immunobiology of Xenotransplantation Cooperative Research Program (IXCRP), a multi-center program dedicated to resolving immunologic and physiologic barriers to safe and efficacious xenotransplantation using preclinical pig to nonhuman primate (NHP) or human decedent models of pancreatic islet, kidney, heart, lung, or liver xenotransplantation. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-AI-24-020.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 353310 Full Announcement-RFA-AI-24-020 -> RFA-AI-24-020-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00285665 | Jul 09, 2024 | Aug 09, 2024 | View |
Package 1
Mandatory forms
353310 RR_SF424_5_0-5.0.pdf
353310 PHS398_CoverPageSupplement_5_0-5.0.pdf
353310 RR_OtherProjectInfo_1_4-1.4.pdf
353310 PerformanceSite_4_0-4.0.pdf
353310 RR_KeyPersonExpanded_4_0-4.0.pdf
353310 PHS398_ResearchPlan_5_0-5.0.pdf
353310 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
353310 PHS_Additional_IndirectCosts_2_0-2.0.pdf
353310 PHS_AssignmentRequestForm_3_0-3.0.pdf
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