The National Human Genome Research Institute (NHGRI) is offering this grant to establish centers dedicated to discovering the genetic variants underlying Mendelian disorders and other health-related Mendelian phenotypes. These centers will utilize genome-wide sequencing and other genomic approaches to uncover the genetic basis of as many phenotypes as possible. This grant is for the purpose of establishing and refining the most effective and efficient designs, technologies, and analysis methods for elucidating genetic bases, balancing cost, efficiency, and quality. NHGRI expects the generated data to determine the tractability of Mendelian phenotypes to current genomic approaches, with the ultimate goal of disseminating this knowledge to accelerate the broader research community’s understanding of Mendelian disorders.
Opportunity ID: 59453
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HG-10-016 |
| Funding Opportunity Title: | Mendelian Disorders Genome Centers (U54) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | 2 |
| Assistance Listings: | 93.172 — Human Genome Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 14, 2010 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Mar 03, 2011 |
| Current Closing Date for Applications: | Mar 03, 2011 |
| Archive Date: | Apr 03, 2011 |
| Estimated Total Program Funding: | $10,000,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) For profit organizations other than small businesses State governments Small businesses County governments Private institutions of higher education Public housing authorities/Indian housing authorities City or township governments Native American tribal governments (Federally recognized) Independent school districts Special district governments Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This FOA seeks to establish a center or centers that will use genome-wide sequencing and other genomic approaches to discover the genetic variants underlying Mendelian disorders and other health-related Mendelian phenotypes in human. The centers should aim to uncover the genetic basis for as many of these phenotypes as possible with the funds available during the funding period. More generally, NHGRI intends that this effort will provide a foundation for the broader research community to elucidate the genetic basis of all Mendelian disorders, and to that end this FOA has two additional purposes that are outlined below.
First, this FOA seeks to establish and refine the most effective and efficient designs, technologies, and analysis methods for elucidating the genetic basis of Mendelian phenotypes. This will necessitate balancing cost, efficiency, and quality. NHGRI expects that the data obtained by the funded projects will help determine the range of tractability of Mendelian phenotypes to state-of-the-art genomic approaches. NHGRI intends that this knowledge will be disseminated to the broader community working on these phenotypes, so that progress towards a comprehensive understanding of the genetic basis of Mendelian disorders will be accelerated. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-10-016.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
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