This grant from the Genomics of Gene Regulation (GGR) initiative explores genomic approaches to understand how DNA sequence regulates gene networks. The goal is to decipher rules of gene network regulation and its impact on cellular function, development, and disease. This funding supports demonstration projects developing and validating models for how sequence-based functional elements regulate genes, using RNA levels. The initiative seeks substantial improvements in gene regulatory network modeling, aiming to predict gene expression accurately from DNA sequence. Awarded projects will form a research consortium, coordinating analytical methods and genomic data to accelerate progress.
Opportunity ID: 239354
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HG-13-012 |
| Funding Opportunity Title: | Genomics of Gene Regulation (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.172 — Human Genome Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 06, 2013 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Nov 15, 2013 |
| Current Closing Date for Applications: | Nov 15, 2013 |
| Archive Date: | Dec 16, 2013 |
| Estimated Total Program Funding: | $10,000,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education Private institutions of higher education Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments For profit organizations other than small businesses State governments Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) solicits applications to start a new initiative, the Genomics of Gene Regulation (GGR), which is intended to explore genomic approaches to understanding the role of genomic sequence in the regulation of gene networks. A long-term goal of functional genomics is to decipher the rules by which gene networks are regulated and to understand how such regulation affects cellular function, development and disease. The GGR initiative will address the genome-proximal component of the regulation of gene networks by supporting a set of demonstration projects to develop and validate models that describe how a comprehensive set of sequence-based functional elements work in concert to regulate the finite set of genes that determine a biological phenomenon, using RNA amounts, and perhaps transcript structure, as the readout. This FOA seeks to support substantial improvement in the methods for developing gene regulatory network models, rather than an incremental improvement on existing methods. This work will move the field closer to the long-term goal of reading DNA sequence and accurately predicting when and at what levels a gene is expressed, in the context of a particular cell state. These demonstration projects will be organized as a research consortium to accelerate progress through the coordination of analytical methods and functional genomic data. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-13-012.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 93.172 | FORMS-C | Forms-C | PKG00182491 | Oct 15, 2013 | Nov 15, 2013 | View |
Package 1
Mandatory forms
239354 RR_SF424_2_0-2.0.pdf
239354 PHS398_ResearchPlan_2_0-2.0.pdf
239354 PHS398_CoverPageSupplement_2_0-2.0.pdf
239354 RR_KeyPersonExpanded_2_0-2.0.pdf
239354 RR_OtherProjectInfo_1_3-1.3.pdf
239354 PerformanceSite_2_0-2.0.pdf
Optional forms
239354 RR_SubawardBudget30_1_3-1.3.pdf
239354 PlannedReport-1.0.pdf
239354 PHS398_CumulativeInclusionReport-1.0.pdf
239354 PHS398_ModularBudget_1_2-1.2.pdf
239354 RR_Budget_1_3-1.3.pdf
Share This Post, Choose Your Platform!
About the Author: osnqt
