This NIH HEAL Initiative grant is for the purpose of funding pilot projects focused on identifying novel druggable targets for pain within the understudied proteome. It aims to support the generation of preliminary data and tools related to eligible understudied proteins. The initiative seeks to jumpstart essential research into these proteins within the context of pain and its management. Successful applicants will utilize funding to conduct basic biochemical and biological work, further characterizing understudied proteins to pinpoint new therapeutic targets for pain. This effort is a crucial part of the broader NIH Helping to End Addiction Long Term (HEAL) initiative, dedicated to accelerating the development of innovative medications across the entire opioid addiction cycle, including chronic use, withdrawal, craving, relapse, and overdose prevention.
Opportunity ID: 353592
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-24-197 |
| Funding Opportunity Title: | HEAL Initiative-Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome (R03 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.121 — Oral Diseases and Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Apr 17, 2024 |
| Last Updated Date: | Dec 11, 2024 |
| Original Closing Date for Applications: | Jul 16, 2026 |
| Current Closing Date for Applications: | Dec 10, 2024 |
| Archive Date: | Jan 09, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $100,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Others (see text field entitled “Additional Information on Eligibility” for clarification) County governments Public housing authorities/Indian housing authorities State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Small businesses For profit organizations other than small businesses Special district governments Native American tribal governments (Federally recognized) Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: |
The purpose of this notice of funding opportunity (NOFO) is to solicit applications for pilot projects to identify new druggable targets for pain within the understudied druggable proteome. Awards will support generation of preliminary data and/or tools around eligible understudied protein(s) listed in this NOFO. This NOFO is intended to jumpstart research on understudied proteins within the context of pain and pain management and provide applicants with sufficient funding to perform basic biochemical and/or biological work to further the characterization of understudied proteins to identify new druggable targets for pain. This NOFO is part of the NIH Helping to End Addiction Long Term (HEAL) initiative to accelerate the development of novel medications to treat all aspects of the opioid addiction cycle, including progression to chronic use, withdrawal symptoms, craving, relapse, and overdose. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-24-197.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Update close date per reissued NOFO PAR-25-154. | Dec 11, 2024 | |
| Apr 17, 2024 |
DISPLAYING: Synopsis 2
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-24-197 |
| Funding Opportunity Title: | HEAL Initiative-Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome (R03 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.121 — Oral Diseases and Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Apr 17, 2024 |
| Last Updated Date: | Dec 11, 2024 |
| Original Closing Date for Applications: | Jul 16, 2026 |
| Current Closing Date for Applications: | Dec 10, 2024 |
| Archive Date: | Jan 09, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $100,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Others (see text field entitled “Additional Information on Eligibility” for clarification) County governments Public housing authorities/Indian housing authorities State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Small businesses For profit organizations other than small businesses Special district governments Native American tribal governments (Federally recognized) Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: |
The purpose of this notice of funding opportunity (NOFO) is to solicit applications for pilot projects to identify new druggable targets for pain within the understudied druggable proteome. Awards will support generation of preliminary data and/or tools around eligible understudied protein(s) listed in this NOFO. This NOFO is intended to jumpstart research on understudied proteins within the context of pain and pain management and provide applicants with sufficient funding to perform basic biochemical and/or biological work to further the characterization of understudied proteins to identify new druggable targets for pain. This NOFO is part of the NIH Helping to End Addiction Long Term (HEAL) initiative to accelerate the development of novel medications to treat all aspects of the opioid addiction cycle, including progression to chronic use, withdrawal symptoms, craving, relapse, and overdose. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-24-197.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
DISPLAYING: Synopsis 1
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-24-197 |
| Funding Opportunity Title: | HEAL Initiative-Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome (R03 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.121 — Oral Diseases and Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Apr 17, 2024 |
| Last Updated Date: | Apr 17, 2024 |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | Jul 16, 2026 |
| Archive Date: | Aug 21, 2026 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $100,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Private institutions of higher education Native American tribal governments (Federally recognized) Small businesses Independent school districts Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Special district governments Native American tribal organizations (other than Federally recognized tribal governments) County governments State governments Public housing authorities/Indian housing authorities City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this notice of funding opportunity (NOFO) is to solicit applications for pilot projects to identify new druggable targets for pain within the understudied druggable proteome. Awards will support generation of preliminary data and/or tools around eligible understudied protein(s) listed in this NOFO. This NOFO is intended to jumpstart research on understudied proteins within the context of pain and pain management and provide applicants with sufficient funding to perform basic biochemical and/or biological work to further the characterization of understudied proteins to identify new druggable targets for pain. This NOFO is part of the NIH Helping to End Addiction Long Term (HEAL) initiative to accelerate the development of novel medications to treat all aspects of the opioid addiction cycle, including progression to chronic use, withdrawal symptoms, craving, relapse, and overdose. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-24-197.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Related Documents
Folder 353592 Full Announcement-PAR-24-197 -> PAR-24-197-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or before January 24, 2025 | PKG00285902 | May 16, 2024 | Dec 12, 2024 | View | |
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289101 | Nov 26, 2024 | Dec 12, 2024 | View |
Package 1
Mandatory forms
353592 RR_SF424_5_0-5.0.pdf
353592 PHS398_CoverPageSupplement_5_0-5.0.pdf
353592 RR_OtherProjectInfo_1_4-1.4.pdf
353592 PerformanceSite_4_0-4.0.pdf
353592 RR_KeyPersonExpanded_4_0-4.0.pdf
353592 PHS398_ResearchPlan_5_0-5.0.pdf
353592 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
353592 RR_Budget_3_0-3.0.pdf
353592 RR_SubawardBudget30_3_0-3.0.pdf
353592 PHS398_ModularBudget_1_2-1.2.pdf
353592 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
353592 RR_SF424_5_0-5.0.pdf
353592 PHS398_CoverPageSupplement_5_0-5.0.pdf
353592 RR_OtherProjectInfo_1_4-1.4.pdf
353592 PerformanceSite_4_0-4.0.pdf
353592 RR_KeyPersonExpanded_4_0-4.0.pdf
353592 PHS398_ResearchPlan_5_0-5.0.pdf
353592 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
353592 RR_Budget_3_0-3.0.pdf
353592 RR_SubawardBudget30_3_0-3.0.pdf
353592 PHS398_ModularBudget_1_2-1.2.pdf
353592 PHS_AssignmentRequestForm_4_0-4.0.pdf
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