This grant is for the purpose of annually estimating influenza vaccine effectiveness (VE) across the United States. Given influenza’s significant burden on public health and the constant evolution of viruses, continuous evaluation of nationwide vaccination programs is crucial. The research will provide timely VE estimates, essential for guiding influenza vaccination and control policies. Studies will encompass populations for whom the CDC’s Advisory Committee on Immunization Practices recommends vaccination. Accurate VE assessment necessitates a comprehensive, multi-component approach, examining vaccination status, laboratory-confirmed outcomes, illness timing, and other factors affecting vaccine use and immune response. Applicants must outline strategies to identify and control potential confounders and modifiers for robust analysis.
Opportunity ID: 63593
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-IP-11-003 |
| Funding Opportunity Title: | Annual Estimates of Influenza Vaccine Effectiveness for Preventing Laboratory-Confirmed Influenza in the United States |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | 5 |
| Assistance Listings: | 93.185 — Immunization Research, Demonstration, Public Information and Education_Training and Clinical Skills Improvement Projects |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jan 10, 2011 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Mar 01, 2011 On-time submission requires that electronic applications be error-free and made available to CDC for processing from eRA Commons on or before the deadline date. Applications must be submitted to and validated successfully by Grants.gov/eRA Commons no later than 5:00 PM Eastern Time. Note:.HHS/CDC grant submission procedures do not provide a period of time beyond the application due date to correct any error or warning notices of noncompliance with application instructions that are identified by Grants.gov or eRA systems (i.e., error correction window). |
| Current Closing Date for Applications: | Mar 01, 2011 On-time submission requires that electronic applications be error-free and made available to CDC for processing from eRA Commons on or before the deadline date. Applications must be submitted to and validated successfully by Grants.gov/eRA Commons no later than 5:00 PM Eastern Time. Note:.HHS/CDC grant submission procedures do not provide a period of time beyond the application due date to correct any error or warning notices of noncompliance with application instructions that are identified by Grants.gov or eRA systems (i.e., error correction window). |
| Archive Date: | Mar 31, 2011 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $785,000 |
| Award Floor: | $0 |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | Centers for Disease Control and Prevention – ERA |
| Description: | Influenza is an important cause of morbidity, mortality, and healthcare burden across all age groups. Because influenza viruses are constantly changing and vaccines are reformulated every year, annual estimates of the effectiveness of influenza vaccines in preventing influenza infection and its associated complications are needed in order to evaluate the protection provided by annual, nationwide vaccination programs. Estimating influenza vaccine effectiveness (VE) as soon as possible after the start of a seasonal influenza epidemic or pandemic and monitoring it over time will be essential in order to guide influenza vaccination and control policy. The populations to be studied will include those for whom CDCs Advisory Committee on Immunization Practices recommends receipt of a licensed influenza vaccine. Influenza vaccination can prevent or reduce a number of outcomes, including laboratory-confirmed influenza virus infection, symptomatic illness given infection, severe illness and related complications due to influenza, the likelihood of transmitting the virus to others, or a combination of these. Thus, accurate estimation of vaccine effectiveness requires a multi-component approach, including accurate assessment of vaccination status, laboratory-confirmed disease outcomes, timing of illness and vaccination, and assessment of other factors that may affect vaccine use and immune response to vaccination. In addition, serological assessment of vaccine response and influenza antibody outcomes among vaccinated and unvaccinated individuals is also needed in order to understand vaccine response. Many additional factors can also affect the assessment of VE in observational studies such as the sensitivity and specificity of outcome measures, specimen collection methods, timing of vaccination, the setting for case and control recruitment, and the ratio of influenza illness to non-influenza respiratory illness. Moreover, a number of potential modifiers of vaccine response and vaccine effectiveness have been identified, including individual factors, environmental factors, and viral and infectious disease factors. Thus, applicants must describe plans to identify and control for a variety of potential confounders in each proposed analysis. |
| Link to Additional Information: | – |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
Centers for Disease Control and Prevention (CDC)
Procurement and Grants Office (PGO) Technical Information and Managment Section (TIMS) Phone 770-488-2700 Email:pgotim@cdc.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 63593 Full Announcement-1 -> ip11-003 foa final amended ii 02.16.11.pdf
Packages
| Agency Contact Information: | Centers for Disease Control and Prevention (CDC) Procurement and Grants Office (PGO) Technical Information and Managment Section (TIMS) Phone 770-488-2700 Email: pgotim@cdc.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 93.185 | NCIRD-R | NCIRD-R | PKG00026390 | Jan 10, 2011 | Mar 01, 2011 | View |
Package 1
Mandatory forms
63593 RR_SF424_1_2-1.2.pdf
63593 RR_OtherProjectInfo_1_3-1.3.pdf
63593 RR_KeyPersonExpanded_1_2-1.2.pdf
63593 RR_Budget-1.1.pdf
63593 PerformanceSite_1_4-1.4.pdf
63593 PHS398_ResearchPlan_1_3-1.3.pdf
63593 PHS398_CoverPageSupplement_1_4-1.4.pdf
63593 PHS398_Checklist_1_3-1.3.pdf
Optional forms
63593 RR_SubawardBudget-1.2.pdf
63593 PHS_CoverLetter_1_2-1.2.pdf
Share This Post, Choose Your Platform!
About the Author: osnqt
