This grant investigates how substances of abuse activate transposable elements and mobile DNA in the brain. These typically silenced genomic elements can then become targets for HIV integration in microglia, causing chromosomal rearrangements and gene dysregulation. This contributes to HIV-associated Neurocognitive Disorder (HAND) and increases HIV reservoir reactivation, particularly in drug users. Understanding these integration factors and the complex interplay among HIV, substance abuse, inflammation, and disease progression is crucial for developing next-generation HIV therapies and potential cures.
Opportunity ID: 337993
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DA-23-003 |
| Funding Opportunity Title: | Investigating Transposable Elements and Mobile DNA as Targets of Integration for Establishing HIV Reservoirs in the Brain (R61/R33 – Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.279 — Drug Abuse and Addiction Research Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Feb 11, 2022 |
| Last Updated Date: | Feb 11, 2022 |
| Original Closing Date for Applications: | Aug 03, 2022 |
| Current Closing Date for Applications: | Aug 03, 2022 |
| Archive Date: | Sep 08, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments Native American tribal governments (Federally recognized) For profit organizations other than small businesses Private institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) City or township governments State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | oMany substances of abuse, including cocaine, methamphetamine, and several opioids exert powerful environmental insults on genomic DNA in the brain that induce expression of transposable elements and other mobile DNA. Transposable elements and mobile DNA, which comprise almost 50% of the human genome, are typically silenced through strong epigenetic modifications. When transposable elements and mobile DNA become active in people who use drugs of abuse, they potentially provide multiple integration sites for HIV in microglia. HIV integration into these unstable regions could lead to major chromosomal rearrangements and global dysregulation of transcription, ultimately contributing to HIV-associated Neurocognitive Disorder (HAND) and providing a mechanism by which drugs of abuse increase the probability of reactivating microglial HIV reservoirs. Understanding the factors that influence HIV integration in these microglial reservoirs is crucial to developing next-generation HIV therapies and potential cures. This concept addresses these gaps by fostering studies aimed at providing a deeper understanding of the complex interplay among HIV, substances of abuse, inflammation, and disease progression. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-23-003.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00272004 | Jul 03, 2022 | Aug 03, 2022 | View |
Package 1
Mandatory forms
337993 RR_SF424_5_0-5.0.pdf
337993 PHS398_CoverPageSupplement_5_0-5.0.pdf
337993 RR_OtherProjectInfo_1_4-1.4.pdf
337993 PerformanceSite_4_0-4.0.pdf
337993 RR_KeyPersonExpanded_4_0-4.0.pdf
337993 RR_Budget_3_0-3.0.pdf
337993 PHS398_ResearchPlan_4_0-4.0.pdf
337993 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
337993 RR_SubawardBudget30_3_0-3.0.pdf
337993 PHS_AssignmentRequestForm_3_0-3.0.pdf
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