This grant, offered by the NHLBI, NIH, invites applications for the Genomics and Informatics Center (GIC) as part of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) program. GRADS aims to assemble a multidisciplinary team to conduct state-of-the-art genomic, microbiomic, and phenotypic studies on Alpha-1 Antitrypsin Deficiency (AAT) and sarcoidosis, two serious lung conditions. The GIC will coordinate clinical centers, perform transcriptome and microbiome analyses on biospecimens, analyze ‘-omic’ data to identify associations with clinical and immune phenotypes, and prepare comprehensive datasets for deposit and distribution to external investigators. This initiative requires strong collaboration among genomic, microbiome, bioinformatic, and clinical scientists specializing in these diseases.
Opportunity ID: 67774
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HL-12-014 |
| Funding Opportunity Title: | Genomic Research in AAT-Deficiency and Sarcoidosis study (GRADS) Cooperative Research Project Grant: Genomics and Informatics Center (GIC) (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.838 — Lung Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Feb 02, 2011 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | May 17, 2011 |
| Current Closing Date for Applications: | May 17, 2011 |
| Archive Date: | Jun 17, 2011 |
| Estimated Total Program Funding: | $12,000,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal governments (Federally recognized) County governments For profit organizations other than small businesses Public and State controlled institutions of higher education Small businesses City or township governments Special district governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this funding opportunity announcement (FOA), issued by NHLBI, NIH, is to invite applications to participate in the NHLBI Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) program, which will assemble a multidisciplinary team of investigators to conduct state-of-art genomic, microbiomics and phenotypic studies of two serious and understudied conditions that affect the lungs: Alpha-1 Antitrypsin Deficiency (AAT) and sarcoidosis. GRADS will include multiple Clinical Centers and one Genomics and Informatics Center (GIC). This FOA solicits applications for the GIC and runs in parallel with a separate FOA that solicits applications for the Clinical Centers (see RFA-HL-12-013). The four main functions of the GRADS GIC are: (1) coordinate activities for the Clinical Centers that will recruit, clinically and immuno- phenotype AAT and sarcoidosis subjects and obtain biospecimens from them, (2) perform transcriptome and microbiome analyses (mRNA, miRNA, viro-, phylo-chip) of the samples obtained by the Clinical Centers, (3) analyze -omic data, testing for associations with the clinical and immune- phenotypes, and (4) prepare a dataset for deposit in the NHLBI BioLINCC repository (https://biolincc.nhlbi.nih.gov/new_data_set_policy/) for distribution to external investigators. This program will require multidisciplinary research collaboration among genomic and microbiome scientists, bioinformaticians, and clinicians with expertise in these diseases. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-12-014.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
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