The Somatic Mosaicism across Human Tissues (SMaHT) Program is offering this grant to establish Genome Characterization Centers (GCCs) as part of the broader SMaHT Network. This initiative aims to advance the discovery of new biological mechanisms and disease pathways by thoroughly investigating genomic variation present in somatic tissues. Successful applicants will operate as GCCs, tasked with generating state-of-the-art, high-throughput genomic data. This involves meticulously characterizing somatic variants identified across a diverse set of 10 to 15 human tissues, sourced from more than 150 distinct donors. Furthermore, these centers will collaborate closely with the SMaHT Data Analysis Center to develop a foundational framework for a comprehensive catalog of these vital somatic variants.
Opportunity ID: 338305
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-RM-22-013 |
| Funding Opportunity Title: | Somatic Mosaicism across Human Tissues (SMaHT) Program: Genome Characterization Centers (UM1 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.310 — Trans-NIH Research Support |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Feb 23, 2022 |
| Last Updated Date: | Feb 23, 2022 |
| Original Closing Date for Applications: | Jul 08, 2022 |
| Current Closing Date for Applications: | Jul 08, 2022 |
| Archive Date: | Aug 13, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education City or township governments Special district governments Private institutions of higher education State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Small businesses County governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This funding opportunity announcement invites applications to establish the Genome Characterization Centers (GCCs) for the Somatic Mosaicism across Human Tissues (SMaHT) Network. ?The purpose of the SMaHT Network is to enable discovery of new biology and disease mechanisms mediated by genomic variation in somatic tissues. The GCCs will be responsible for generating state of the art, high throughput genomic data characterizing somatic variants in a set of 10-15 human tissues from 150+ donors. The GCCs will work closely with the SMaHT Data Analysis Center to build the framework for a comprehensive catalog of variants. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-22-013.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 338305 Full Announcement-RFA-RM-22-013 -> RFA-RM-22-013-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00272205 | Jun 08, 2022 | Jul 08, 2022 | View |
Package 1
Mandatory forms
338305 RR_SF424_5_0-5.0.pdf
338305 PHS398_CoverPageSupplement_5_0-5.0.pdf
338305 RR_OtherProjectInfo_1_4-1.4.pdf
338305 PerformanceSite_4_0-4.0.pdf
338305 RR_KeyPersonExpanded_4_0-4.0.pdf
338305 RR_Budget_3_0-3.0.pdf
338305 PHS398_ResearchPlan_4_0-4.0.pdf
338305 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
338305 RR_SubawardBudget30_3_0-3.0.pdf
338305 PHS_AssignmentRequestForm_3_0-3.0.pdf
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