This grant, the Botanical Dietary Supplement Research Centers (P50), is for supporting research centers that will employ cutting-edge, transdisciplinary approaches to study botanicals relevant to human health, especially those found in dietary supplements. The focus is on conducting innovative basic and preclinical research to elucidate interactions between complex botanical products and human biology. The long-term goal is to generate robust preclinical data, including mechanisms of action, optimal formulations, and dosing, essential for designing definitive clinical research. This initiative encourages the use of relevant vertebrate and invertebrate models, with limited human subjects research permitted to investigate in vivo mechanisms, safety, pharmacokinetics, or individual differences in response.
Opportunity ID: 248914
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-OD-14-001 |
| Funding Opportunity Title: | Botanical Dietary Supplement Research Centers (P50) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.213 — Research and Training in Complementary and Alternative Medicine |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 05, 2013 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Jun 06, 2014 |
| Current Closing Date for Applications: | Jun 06, 2014 |
| Archive Date: | Jul 07, 2014 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $1,250,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) County governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Special district governments Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education State governments City or township governments Independent school districts For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Public housing authorities/Indian housing authorities |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) invites applications to support research centers to develop and apply cutting-edge, transdisciplinary approaches to the study of botanicals with relevance to human health, that are found as ingredients in dietary supplements. These centers are expected to synergistically integrate a range of relevant disciplines (e.g., phytochemistry, botany, and expertise utilizing models ranging from in silico through in vitro to in vivo) to conduct innovative research to elucidate the interactions between complex botanical products and human biology. The long-term goal of this program is to support development of the preclinical data required for optimal design of rigorous, definitive clinical research on complex botanical products. Given the extensive resources required for clinical research it is critical that clinical trials of botanicals be supported by solid and extensive relevant preclinical data, especially with respect to mechanisms of action, optimal formulations and dosing, for example. Therefore the focus of these Centers will be on basic and preclinical research. The focus of this FOA is on research on the mechanisms of action of botanicals traditionally used for health maintenance, or on botanicals with strong evidence of promise for improving objective, quantitative measures of organism resilience. Use of relevant vertebrate and invertebrate models is strongly encouraged. A strictly limited number of human subjects research aims, designed to interrogate, e.g., in vivo mechanism(s) of action, safety, pharmacokinetics, or bases of individual differences in metabolism or response, may be included. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-OD-14-001.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 93.213 | FORMS-C | Forms-C | PKG00190711 | May 06, 2014 | Jun 06, 2014 | View |
Package 1
Mandatory forms
248914 PHS398_ResearchPlan_2_0-2.0.pdf
248914 PHS398_CoverPageSupplement_2_0-2.0.pdf
248914 RR_KeyPersonExpanded_2_0-2.0.pdf
248914 RR_OtherProjectInfo_1_3-1.3.pdf
248914 PerformanceSite_2_0-2.0.pdf
248914 RR_SF424_2_0-2.0.pdf
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