The National Institutes of Health (NIH) is offering this R01 grant to advance the understanding of molecular mechanisms underpinning addictive processes through basic functional genetic and genomic research. While initial studies identified candidate genes and variants, this grant encourages two key areas: first, the functional validation of these candidate genes, variants, epigenetic features, and non-coding RNAs to confirm their authentic role in addiction. Second, it supports the detailed elucidation of specific molecular pathways and processes modulated by these candidates, particularly for those with previously unanticipated roles in addiction. This initiative aims to deepen mechanistic comprehension of substance abuse at the genetic and genomic level.
Opportunity ID: 248925
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-14-014 |
| Funding Opportunity Title: | Functional Genetics, Epigenetics, and Non-coding RNAs in Substance Abuse (R01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.279 — Drug Abuse and Addiction Research Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 05, 2013 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Jan 07, 2017 |
| Current Closing Date for Applications: | Jan 07, 2017 |
| Archive Date: | Feb 07, 2017 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Public and State controlled institutions of higher education County governments Native American tribal governments (Federally recognized) Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Public housing authorities/Indian housing authorities State governments Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Genetic and genomic studies have identified genes and gene variants that potentially modulate the fundamental biological mechanisms underpinning addictive processes. Discovery of these genes/variants, while extremely valuable, is only a first step in understanding molecular mechanisms of addiction. This Funding Opportunity Announcement encourages basic functional genetic and genomic research in two areas: 1. functional validation to determine which candidate genes/variants/epigenetic/non-coding RNA features have an authentic role in addictive processes, and 2. detailed elucidation of the molecular pathways and processes modulated by candidate genes/variants, particularly for those genes with an unanticipated role in addiction. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PA-14-014.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 93.279 | FORMS-C | Forms-C | PKG00190740 | Jan 05, 2014 | May 07, 2016 | View |
| FORMS-D | Use for due dates on or after May 25, 2016 | PKG00222106 | Apr 17, 2016 | Jan 07, 2017 | View |
Package 1
Mandatory forms
248925 RR_SF424_2_0-2.0.pdf
248925 PHS398_ResearchPlan_2_0-2.0.pdf
248925 PHS398_CoverPageSupplement_2_0-2.0.pdf
248925 RR_KeyPersonExpanded_2_0-2.0.pdf
248925 RR_OtherProjectInfo_1_3-1.3.pdf
248925 PerformanceSite_2_0-2.0.pdf
Optional forms
248925 RR_SubawardBudget30_1_3-1.3.pdf
248925 PlannedReport-1.0.pdf
248925 PHS398_CumulativeInclusionReport-1.0.pdf
248925 PHS398_ModularBudget_1_2-1.2.pdf
248925 RR_Budget_1_3-1.3.pdf
Package 2
Mandatory forms
248925 RR_SF424_2_0-2.0.pdf
248925 PHS398_CoverPageSupplement_3_0-3.0.pdf
248925 RR_OtherProjectInfo_1_3-1.3.pdf
248925 PerformanceSite_2_0-2.0.pdf
248925 RR_KeyPersonExpanded_2_0-2.0.pdf
248925 PHS398_ResearchPlan_3_0-3.0.pdf
Optional forms
248925 RR_Budget_1_3-1.3.pdf
248925 RR_SubawardBudget30_1_3-1.3.pdf
248925 PHS398_ModularBudget_1_2-1.2.pdf
248925 PHS_Inclusion_Enrollment_Report-1.0.pdf
248925 PHS_AssignmentRequestForm-1.0.pdf
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