This grant is for supporting innovative research into how HIV infection and substance use disorders (SUD) affect the blood-brain barrier (BBB) and its integrity. The BBB, a target for HIV and abused substances, is critical in regulating their entry into the brain. The initiative aims to elucidate the basic molecular mechanisms by which HIV and addictive substances compromise BBB function, leading to virus crossing and neurological pathology. Studies are encouraged to expand current understanding of virus mobilization across the BBB and its pathology in HIV and SUD. Furthermore, the grant supports developing and testing novel BBB models to assess the delivery of pharmacological and immunotherapies, crucial for treating HIV infection and SUD, and suppressing HIV replication within the central nervous system.
Opportunity ID: 339850
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DA-23-012 |
| Funding Opportunity Title: | Pathogenic Mechanisms influencing Blood Brain Barrier function in HIV and Substance Use Disorders (R01 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.279 — Drug Abuse and Addiction Research Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Apr 26, 2022 |
| Last Updated Date: | Apr 26, 2022 |
| Original Closing Date for Applications: | Aug 11, 2023 |
| Current Closing Date for Applications: | Aug 11, 2023 |
| Archive Date: | Sep 16, 2023 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments City or township governments Special district governments State governments Public housing authorities/Indian housing authorities Private institutions of higher education Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The blood brain barrier (BBB) is a target of both the HIV virus and substances of abuse. It is a site of entry for HIV infected monocytes and macrophages that can traverse the BBB either paracellularly or transcellularly. HIV viral proteins can also attack astrocytes and tight junctions of BBB directly and compromise its integrity, resulting in the crossing of the virus, as well as abused substances, into the brain. Meanwhile, many substances of abuse cause BBB dysfunction. Because BBB integrity regulates both substances and virus levels in the brain, it is critical to establish the mechanisms by which HIV infection, in combination with substances of abuse, affect BBB function and integrity and their consequences. The purpose of this initiative is to support innovative research that elucidates the roles of HIV and addictive substances in the pathology of BBB. This FOA encourages studies to expand the current understanding of the basic molecular mechanisms underlying virus mobilization across BBB, and pathology of BBB in HIV infection and substance use disorders (SUD). In addition, studies are encouraged to develop and test novel BBB models to assess the delivery of pharmacological and immunotherapies to treat HIV infection and SUD, and to suppress HIV replication in CNS. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-23-012.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 339850 Full Announcement-RFA-DA-23-012 -> RFA-DA-23-012-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or before January 24, 2023 | PKG00273701 | Jul 11, 2022 | Jan 24, 2023 | View | |
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00277849 | Nov 01, 2022 | Aug 11, 2023 | View |
Package 1
Mandatory forms
339850 RR_SF424_5_0-5.0.pdf
339850 PHS398_CoverPageSupplement_5_0-5.0.pdf
339850 RR_OtherProjectInfo_1_4-1.4.pdf
339850 PerformanceSite_4_0-4.0.pdf
339850 RR_KeyPersonExpanded_4_0-4.0.pdf
339850 PHS398_ResearchPlan_4_0-4.0.pdf
339850 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
339850 RR_Budget_3_0-3.0.pdf
339850 RR_SubawardBudget30_3_0-3.0.pdf
339850 PHS398_ModularBudget_1_2-1.2.pdf
339850 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
339850 RR_SF424_5_0-5.0.pdf
339850 PHS398_CoverPageSupplement_5_0-5.0.pdf
339850 RR_OtherProjectInfo_1_4-1.4.pdf
339850 PerformanceSite_4_0-4.0.pdf
339850 RR_KeyPersonExpanded_4_0-4.0.pdf
339850 PHS398_ResearchPlan_5_0-5.0.pdf
339850 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
339850 RR_Budget_3_0-3.0.pdf
339850 RR_SubawardBudget30_3_0-3.0.pdf
339850 PHS398_ModularBudget_1_2-1.2.pdf
339850 PHS_AssignmentRequestForm_3_0-3.0.pdf
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