This grant aims to develop advanced multi-organ automated microphysiological systems (MPS) to investigate microgravity’s effects on the human body within the International Space Station National Laboratory (ISS-NL). The program seeks to provide critical insights into human patho(physiology), particularly concerning aging-related functional decline and associated diseases. By utilizing multi-organ MPS, the initiative will facilitate more comprehensive whole-organism modeling. Enhanced automation and extended system longevity are crucial for conducting prolonged experiments in space, enabling the collection of highly physiologically relevant data. Furthermore, incorporating samples representing broad human population diversity will improve the modeling of aging progression and aid in developing targeted interventions. This funding opportunity is essential for advancing personalized medicine and drug efficacy/toxicity testing in space environments.
Opportunity ID: 355661
General Information
Document Type: | Grants Notice |
Funding Opportunity Number: | RFA-TR-24-025 |
Funding Opportunity Title: | Tissue Chips in Space 2.0: Translational Multi-Organ Tissue Chip Systems for Drug Efficacy, Toxicity Testing, and Personalized Medicine in Human Health, Aging and Associated Diseases (UG3/UH3 Clinical Trial Not Allowed) |
Opportunity Category: | Discretionary |
Opportunity Category Explanation: | – |
Funding Instrument Type: | Cooperative Agreement |
Category of Funding Activity: | Health |
Category Explanation: | – |
Expected Number of Awards: | – |
Assistance Listings: | 93.350 — National Center for Advancing Translational Sciences |
Cost Sharing or Matching Requirement: | No |
Version: | Synopsis 1 |
Posted Date: | Jul 25, 2024 |
Last Updated Date: | Jul 25, 2024 |
Original Closing Date for Applications: | Oct 18, 2024 |
Current Closing Date for Applications: | Oct 18, 2024 |
Archive Date: | Nov 23, 2024 |
Estimated Total Program Funding: | – |
Award Ceiling: | $750,000 |
Award Floor: | – |
Eligibility
Eligible Applicants: | Special district governments Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments For profit organizations other than small businesses Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities County governments Private institutions of higher education Public and State controlled institutions of higher education Independent school districts City or township governments Native American tribal organizations (other than Federally recognized tribal governments) |
Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
Agency Name: | National Institutes of Health |
Description: | The purpose of this Notice of Funding Opportunity (NOFO) is to develop multi-organ automated microphysiological systems (MPS) for studying the effects of microgravity conditions on human body in low Earth orbit at the International Space Station National Laboratory (ISS-NL). This program will provide insights on human patho(physiology), especially aging-related functional decline and age-related diseases. The multi-organ MPS configuration will allow better modeling of the whole organism. Improved automation with extended longevity of MPS will facilitate longer experiments in space and the collection of more physiologically relevant data. The inclusion of samples representing the broad spectrum of diversity in the human population will allow for better modeling of aging progression and development of interventions. |
Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-TR-24-025.html |
Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
Version | Modification Description | Updated Date |
---|---|---|
Related Documents
Folder 355661 Full Announcement-RFA-TR-24-025 -> RFA-TR-24-025-Full-Announcement.pdf
Packages
Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
Who Can Apply: | Organization Applicants |
Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
---|---|---|---|---|---|---|
FORMS-H | Use for due dates on or after January 25, 2023 | PKG00287492 | Sep 18, 2024 | Oct 18, 2024 | View |
Package 1
Mandatory forms
355661 RR_SF424_5_0-5.0.pdf
355661 PHS398_CoverPageSupplement_5_0-5.0.pdf
355661 RR_OtherProjectInfo_1_4-1.4.pdf
355661 PerformanceSite_4_0-4.0.pdf
355661 RR_KeyPersonExpanded_4_0-4.0.pdf
355661 RR_Budget10_3_0-3.0.pdf
355661 PHS398_ResearchPlan_5_0-5.0.pdf
355661 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
355661 RR_SubawardBudget10_30_3_0-3.0.pdf
355661 PHS_AssignmentRequestForm_3_0-3.0.pdf