This grant from the NIH Blueprint Neurotherapeutics Network (BPN) is for neuroscience investigators aiming to accelerate small molecule drug discovery and development for nervous system disorders into clinical trials. Applicants will conduct disease- and target-specific research in their own laboratories with funding provided. Awardees also benefit from collaboration with NIH-funded consultants and access to NIH contract research organizations, offering expertise in medicinal chemistry, pharmacokinetics, toxicology, formulations, chemical synthesis (including GMP), and Phase I clinical testing. Projects can enter at the Discovery stage to optimize compounds or at the Development stage for IND-enabling studies and Phase I testing. Institutions retain and control intellectual property rights for developed drug candidates.
Opportunity ID: 356531
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-051 |
| Funding Opportunity Title: | Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development of Disorders of the Nervous System (UG3/UH3 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.121 — Oral Diseases and Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Sep 25, 2024 |
| Last Updated Date: | Sep 25, 2024 |
| Original Closing Date for Applications: | Aug 18, 2026 |
| Current Closing Date for Applications: | Aug 18, 2026 |
| Archive Date: | Sep 23, 2026 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments Public and State controlled institutions of higher education Special district governments Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Small businesses Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Private institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The Blueprint Neurotherapeutics Network (BPN) invites applications from neuroscience investigators seeking support to advance their small molecule drug discovery and development projects into the clinic. Participants in the BPN are responsible for conducting all studies that involve disease- or target-specific assays, models, and other research tools and receive funding for all activities to be conducted in their own laboratories. In addition, applicants will collaborate with NIH-funded consultants and can augment their project with NIH contract research organizations (CROs) that specialize in medicinal chemistry, pharmacokinetics, toxicology, formulations development, chemical synthesis including under Good Manufacturing Practices (GMP), and Phase I clinical testing. Projects can enter either at the Discovery stage, to optimize promising hit compounds through medicinal chemistry to the Development stage, to advance a single development candidate through Investigational New Drug (IND)-enabling toxicology studies and phase I clinical testing. Alternatively, projects can enter at the Development stage and progress in a shorter period to IND enabling toxicology studies and phase I clinical testing. BPN awardee Institutions retain their assignment of IP rights and gain assignment of IP rights from the BPN contractors (and thereby control the patent prosecution and licensing negotiations) for drug candidates developed in this program. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-051.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 356531 Full Announcement-PAR-25-051 -> PAR-25-051-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288381 | Dec 27, 2024 | Aug 18, 2026 | View |
Package 1
Mandatory forms
356531 RR_SF424_5_0-5.0.pdf
356531 PHS398_CoverPageSupplement_5_0-5.0.pdf
356531 RR_OtherProjectInfo_1_4-1.4.pdf
356531 PerformanceSite_4_0-4.0.pdf
356531 RR_KeyPersonExpanded_4_0-4.0.pdf
356531 RR_Budget10_3_0-3.0.pdf
356531 PHS398_ResearchPlan_5_0-5.0.pdf
356531 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
356531 RR_SubawardBudget10_30_3_0-3.0.pdf
356531 PHS_AssignmentRequestForm_4_0-4.0.pdf
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